Recommended drink: [[MustHaveCaffeine coffee]] (preferably decaf to avoid a caffeine overdose).

* Take a shot every time somebody:
** starts going out with someone.
** breaks up with someone.
** has sex.
** gets married.
** has a baby.
* Take a shot every time Chandler [[DeadpanSnarker makes a joke]].
** Two if it involves sarcasm.
** Three if Joey doesn't get it.
* Take a shot when characters say their most known catchphrases:
** Ross says "WE WERE ON A BREAK!"
** Chandler says some variant of "Could X ''be'' any more Y" (although he actually doesn't do this much).
*** Or if another character uses this to do an impression of Chandler (which actually happens just as often).
** Joey says "How you doin'" to a woman.
** Phoebe uses her distinctive way of saying "Oh no".
** Phoebe uses the fake name "Regina Phalange".
* Whenever Joey and somebody else / several somebody elses find out something at the same time, and the other person/people react immediately but Joey does not, starting drinking and keep going until Joey finally puts 2 and 2 together and reacts.
* Take a shot every time Joey tries to flirt with a girl. Two if he succeeds.
* Take a shot every time Monica [[NeatFreak freaks out]] about something not being clean/being in the wrong place.
* Take a shot whenever Gunther pines for Rachel.
* If there's a big secret, take a shot whenever [[KeepingSecretsSucks someone finds out]].
* Take a shot whenever you can see someone's nipple protrusions in their shirt. [[MsFanservice Two if they're Rachel's]].
* Take a shot when Phoebe sings. Make it two if it's "Smelly Cat"
* Drink when Janice comes in unannounced and says "OH! MY!!! GOD!!!!!"

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An alternative, simpler game:
* Drink every time the audience makes a noise. Laugh track, "Oooooh" etc.