No ALLCAPS, no bold, and no italics unless it's the title of a work. We are not yelling the DMoSs out loud.
Knight9910: In my opinion the real worst VG Cats strip was #259: The Comedian, or more specifically it was The Comedian, before it was edited and the part where Leo confessed to raping and murdering Aeris' mom was replaced with a lame joke about anal. (Related note: changing the original to just a series of lame jokes really just means Aeris is the one who crosses the Moral Event Horizon for murdering Leo for what amounts to... well, a series of lame jokes; nobody wins here.) It's bad enough Scott made that one, but then he made the next strip into an insult aimed at anyone who didn't like 259, under the pretense that they were offended by the abortion thing, as opposed to them being offended by the fact that he'd suddenly changed lovable dimwit Leo into a seriously disturbed sociopath with no redeeming qualities or by the fact that a quirky comic about video games was now about Leo being a mentally ill sociopath with no redeeming qualities. That almost made me stop reading the comic altogether.
Midna: That Scott would make a rebuttal strip at all to mock people who didn't like the previous strip says a lot. A simple "If you can't stomach the comic, you shouldn't be reading it" would have sufficed. We didn't need to see a cat eating one of the members of a dance group made up of aborted fetuses. Wasn't this strip about video games anyway?
biznizz: The "Nerd Rage" one nearly broke me, but the one that was it for me was this abomination. In it, Scott using his Author Avatar Aeris, expresses his rage & disbelief that gamers use other mediums which touch upon games & game franchises. Basically, Scott says if you want backstory and world building novels / comics / whatever, something is wrong with you. Go piss off, Scott.
So We Ate Them: Same troper, different webcomic; VG Cats. This strip. Misogyny for shock value? That can be let fly. Misogyny, realistically portrayed misogyny, as the punchline of a joke! You don't do that. You just don't.
Scarlet Wave: What really solidifies this as VG Cats's nadir is that the second-to-last panel tied up the joke (commentary about sexism in games) perfectly well, yet the author believed that adding the last panel would make the comic funnier.
Tropers/Chilliwack: Strip #363. Leo was supposed to paint the whole place blue, but he wasted time painting the walls. And so in a last ditch effort to create a "blue" atmosphere, he shouts out "Iwata's Dead!"... Get it? It's funny because someone died. This was in extremely bad taste, even for VG Cats. Especially when you consider than Iwata was one of the most respected and beloved figureheads of gaming in recent years, at least by CEO standards.
Background Guy: I can handle all the more abrasive stuff, and I can't remember one strip in particular when things started to go wrong. It's been a gradual downward trajectory for several years. My general gripes are that the artwork has gotten more detailed but even worse, and the characters have become unlikable. But probably the worst thing of all is that the humor just isn't what it was anymore. For proof, look no further than this one: #367 Moostache. Take a gag that wasn't terribly funny to start with, then have Leo really hammer it home so that we know exactly what's going on (I'm the one who added this under Don't Explain the Joke on the comic's main trope page). He's clearly just phoning it in these days. This is Seltzerberg levels of suck.
Kablammin 45: Taking back my previous entry for a different comic that, while not making me uncomfortable like my previous entry, just left me annoyed. This different comic would be: My Strange Addiction, a comic about the Nintendo Switch. For one thing, Scott treats the Switch as a solely portable console with no mention of the console side of the Switch in sight, which either reeks of him not doing the research or intentionally ignoring it to further his arguments. Scott comparing the Switch to the PlayStation Vita really doesn't make any sense (any similarities are superficial, at best), nor does him saying (in layman's terms): "But don't we have the 3DS? Why are you making a new portable console?" (As mentioned before, the Switch is a hybrid console that Nintendo doesn't plan on replacing the 3DS with at this time anyway.) Finally, there's how he portrays the guy who owns a Switch console in the comic. Granted, I can understand the Fridge Logic in taking the Switch to a basketball game to play a basketball game on it, but the rest of the comic shows the guy as some obnoxious idiotic Jerkass who can't go anywhere without shoving the Switch in someone's face (including having the guy creepily stalking a woman who also has the console) and disrupting a party just to play it in front of the people there. Maybe I'm looking too far into this part, but it kinda makes you wonder if this is how Scott sees Nintendo fans. Between the rather fallacious sounding arguments and the fact that the behavior of the guy can be construed as a Take That! at Nintendo fans, this comic just comes off as a big and unfunny mess.
Beacon 80: For me it was this strip. We were still getting announcements on characters, and the idea that longrunners like Captain Falcon and Jigglypuff weren't going to make it was laughable. That was when I realized that this was the only laugh I'd gotten out of the comic in ages, and it was at him, not with him.
Heartlesswithaheart: Withdrawing my previous entry to replace it with #371 Tremendous. It's the same unfunny political jokes that have plagued 2016's US election, only recycled using Sonic characters. While it would have been relevant (and maybe at least somewhat amusing) back then, it was released in 2017 after president 45 is already in office. It feels less like the legitimately amusing comic it used to be and more like a shoddy fanfiction using popular characters to voice the creator's opinions. This has been a problem for a while, but this has been the most blatant.