- Girl Genius: "Let me tell you about Airman Higgs."
"I am Gilgamesh Wulfenbach, little man - and there is nothing I couldn't do, had I cause! And now... now I have one!"
- Airman Higgs got Baron Wulfenbach out of a burning airship and to safety. During which, he had to deal with a bunch of monsters, an irate Captain Dupree, and a goose, breaking three out of four limbs in the process and getting an infected bite. He managed to get to a town despite his injuries, where he got shot in his last undamaged limb. He informed the local garrison of Wulfenbach's predicament, then passed out.
- Then shows up here and here fighting off a Muse that is possessed/occupied by the Heterodyne Castle's AI.
- "You cannot kill Mr. Higgs. You cannot stop Mr. Higgs. You cannot even run from Mr. Higgs."
- Gil has his Determinator moments as well, especially when Agatha is in danger:
- The Order of the Stick's side character O-Chul, whom Big Bad Xykon is speaking of in the Quotes Wiki. Just see for yourself.
"It's Xykon's spell list. Or most of it, anyway." "Are you kidding?!? How did you get this??" "One saving throw at a time."
- Roy himself sometimes displays Determinator qualities, especially right before Xykon kills him.
- Laura from Collar 6...well, when Ginger is watching, anyway.
- The title character from Dr. McNinja.
- In Homestuck, Sollux Captor manages to get Feferi Peixes into the Medium while he and the rest of the troll species were being mind raped to death by the cry of an Eldritch Abomination. Feferi later returns the favor.
- Sollux does it again when he telekinetically flies the troll's asteroid toward the beacon of the Green Sun, their only hope of survival, at the rapid speed necessary to get there before the beacon's path fades. The strain is so great that he bleeds from every orifice before ultimately dying permanently of it.
- Terezi Pyrope also deserves mention, having raised herself almost completely alone from infancy on Alternia, a freaking Death World.
- This would be amazing already without the fact that she is blind.
- Kanaya after getting fatally shot by Eridan, manages to pick herself up and escape offscreen. During Nepeta's time wandering around she finds a trail of Jade blood and a destroyed transportalizer. When she confronts the three who've gone rogue she's Eridan's cape around her wound as a sash, which has since soaked through with her blood and she still takes them down.
- Gamzee Makara has recently taken things to a new level with the revelation that he has managed to survive through will alone, throughout every timeline, including ones in which a psychic shriek was emitted that is fatal to his entire species. He's also still moving in the alpha timeline, despite taking 5 minutes worth of automatic fire from Caliborn's Machine Gun.
- Vriska is obsessed with being the most important character of the plot, essentially orchestrating (Or at least so she thinks) every major event of the Alpha timeline. Even after she died, she's still hell bent in being the one to defeat lord English by rallying up an army of ghosts in the void between universes. Taking this trope to its logical extent, she will even directly challenge the narrator/writer of the comic psychically in order to get back in the spotlight and finish her Story Arc properly.
- Perhaps more impressive are her actions during the revenge cycle. After Terezi causes the cueball to blow up in her face (removing her right arm and eye) she regains consciousness and immediately performs a double psychic reacharound (mindcontrolling Tavros to use his powers to control a dragon to use its connection to Terezi to mind control her into blinding herself) to get her revenge, and is still mad enough to taunt Terezi over a chat client before passing out due to bloodloss.
- Karkat might qualify as well, because on Alternia, being (as previously stated) is a Death World, where just surviving is a feat, not only does he survive, he does so living in a world where his ENTIRE EXISTENCE is a crime punishable by death because of his blood colour, but he does so while living in close proximity to other trolls. Which means, because of troll biology, he would never be able to cry, blush, bleed or have sex. EVER. The last of which, in troll society, also means death. Terezi teases him about it mercilessly.
- Caliborn. It is impossible to win a session with just one player. Caliborn does it anyway. He is a Time player, which means he can go back in time and redo things until he gets them right. Out of sheer stubborness, he achieves all of the levels, by himself, just by level grinding for years and years, solves all of the puzzles despite his learning disability, and eventually becomes the most powerful villain in the universe. On a lesser level, Caliborn's art is absolutely terrible. Everyone who sees it tells him that it is, and that he should stop drawing, but he draws anyway, confident that he will become a great artist. His art has improved immensely from the start of the story, from "incomprehensible" to "bad" to merely "poor", so that just goes to show he was right not to listen to the haters.
- The Inexplicable Adventures of Bob!: Fructose Riboflavin, who has been trying to take over the Nemesite Empire for the better part of two thousand years. He's now very old and tired. He's pretty good at knowing when he's lost a battle, he can even be gracious about it, but he never concedes the war, and he's virtually impossible to keep locked up even briefly. Although his sheer frenzied desire for his goal can lead to occasional Villainous Breakdowns.
- The canadian lumberjack in Antihero for Hire certainly adheres to the trope strongly, as seen here. Some of MANTIS's agents, especially the elites, qualify.
- El Goonish Shive: Nanase was the only one able to protect Ellen from the Knight Templar trying to kill her, but the only thing she could do was summon a doll-sized version of herself at Ellen's position, though she could still throw full-powered punches in that form. She would get a few hits in, and then the Knight Templar would destroy the doll, which'd give her damaging feedback. So she'd summon another one...and another....and another...
- The sysadmin in this xkcd.
- Marah is showing signs of becoming one  modestmedusa
- Dominic Deegan has The Infernomancer. No matter if he's devestated by holy magic, blasted by chaos infused black magic, banished to an alternate dimension full of eldritch abominations, or sent directly to hell, he just... Doesn't... Die...
- Link, from The Legend of Zelda, as portrayed in a comic by Zac Gorman.
- Anne from Sunstone puts a startlingly large amount of time and effort into getting Alan to cross dress. This infliction was caught by the fans when Sejic hinted this would actually happen after an outrageous amount of page views.
- Jacob's persona of Target Man in Precocious, with the power to absorb all hits and keep getting up.
- Dragon Ball Multiverse:
- Nail. Holy shit.
- It took a lot for Recoome to go down, too.
- On a more humorous note, Dabura manages to survive a giant fucking hole in his chest far longer than should be possible.
- Ludwig in A Day With Bowser Jr. He is so hell-bent on murdering Bowser Jr and claiming back the Koopa throne, that literally all of his dialogue revolves around his desire for the throne. He's even thinking about killing Bowser Jr while bedridden and severely injured!
- Questionable Content: "My name is Hannelore Ellicott-Chatham. I end messes."note
- Dumbing of Age This praise from Sarah
You will do it. It might work, it might not, but you will do it. And you will keep doing it, for her. Because you are relentless. You will never stop doing whatever you can for her, ever. And because of that, ultimately, she will be fine.