The Duracell/Energizer bunny. It keeps going and going and going...
The Trix rabbit, and many other mascots for kids' cereal.
In Brasil there was once a series of advertisements of people getting better in life that always ended with the sentence "...porque (ele/a) é brasileiro/a e não desiste nunca.", or, in English, "...because (he/she) is Brazilian and never gives up.". It became a Memetic Mutation. In other words, the Brazilian government made the citizenry consider themselves Memetic Determinators.
John Jameson, according to this ad for Jameson's Whiskey, here. The man battled Cthulhu just to get back a barrel of his beloved whiskey.