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Despair Event Horizon:
In , an Keychain of Creation webcomic, this is canonically how Abyssal Exalted get created, as shown in Renegade Deathknight Secret's backstory flashback. Her entire village is killed by a demonic plague, she's deathly ill, and just as she's given up all hope of living, the Neverborn show up and offers her Exaltation in exchange for servitude.
Exalted , Lucy when Bittersweet Candy Bowl she thought Mike died and shortly after, when she finally confessed her love for him and he rejected her. The first one came with Dissonant Laughter.
Chapter 63 is getting sadder and Lucy looks about at the horizon here. She was okay, then Mike ignored her existence. Now...
In , Homestuck Eridan crosses both this and the Moral Event Horizon in the same scene. He gives up any hope of beating Jack and defects to his side, killing off his unrequited love interest AND his species' only hope for revival in the process. This makes his Sgrub title, Prince of Hope, rather prophetic- it was later explained that "Prince" roughly translates to "Destroyer."
Trudy crosses this in after seeing Nick, (whom she had loved) propose to Ki, which Ki accepts. She had been starting to regret her actions, but this pushes her even further, and she attempts suicide in the next arc in which she appears.
General Protection Fault In Goblin Hollow, this is what happens to Penny's best friend, who sadly,
is swallowed by the Horizon. has True Believers Spider-Man lose his wife, his home, and his job at the Daily Bugle all in the first 11 pages. As a result, he asks Dr. Octopus to kill him. Unfortunately for him, Death Is Cheap in the Marvel Universe, so not even murder can end his suffering.
Sinfest has Vaarsuvius crossing the line after realizing the true extent of his/her earlier The Order of the Stick Moral Event Horizon.
In , Claire's No Rest for the Wicked Dark and Troubled Past has brought her to the state that she does not even care that the villagers, looking for The Scapegoat, will Burn the Witch! because they think she killed her children.
Very nearly everyone with a speaking part in , though it doesn't manifest in quite the usual way. Rather than some grand gesture like falling into an Gone with the Blastwave Angst Coma or being Driven to Suicide , they've all just become desensitized to the constant bloodshed and are operating on some sort of note Heroic Safe Mode.
Matt from Hodges Pond came pretty close to crossing it in this strip.
Anna Enfield's from '' Sire' lead a fairly troubled life which took a sharp turn when the sister that she shared a body with used it to murder their beloved uncle. Having seen herself kill someone she loved and knowing that her Hyde half could not do that unless she desired it, Anna turns a knife on herself and tries to commit suicide.