%% This list of examples has been alphabetized. Please add your example in the proper place. Thanks!

* During Makoto's ''Help Me!!'' segment in ''[[VideoGame/BlazBlueContinuumShift BlazBlue: Continuum Shift EXTEND]]'', Kokonoe demands that Makoto [[ACupAngst explain her shelf]], to which she responds "You want me to explain furniture?" While this would be a typical response from a {{ditz}} and fit this trope under normal circumstances, the look on her face suggested she ''knew'' what Kokonoe was talking about, and she missed the point on purpose.
** Another one in Valkenhayn's gag reel. Valky describes the legend of the "[[LittleMissBadass Sleeping Crimson-Eyed Pigtails]]" and goes on to mention that even Hakumen pees himself at the mere mention of it. Ragna's response?:
-->'''Ragna''': "[[AnimatedArmor He ''pees]]''?"
** Also happens in Litchi's gag reel. Taokaka forces a select few characters to play a magical board game, in which the player abides by the rules or else. [[ButtMonkey Bang Shishigami]] falls on a square that forces him to get ''brutally beaten the crap outta him by a metal bat'', which the game itself provides. The other player's responses?
-->'''Rachel''': "My, what a fine bat!"
-->'''Tager''': "Hmm... Well, I have to admit, that ''is'' a very nice metal bat."
* Very common in ''VideoGame/CrusadersOfTheLostIdols''. For one, you just don't seem to get what a necromancer ''is''.
-->"Necroqueen Katriana! What have you done with Necromancer Kate?"
* ''VideoGame/TheDarksideDetective'': Common on the part of [=McQueen=]'s sidekick Dooley.
** Several cases begin with Dooley calling [=McQueen=] to the scene of an occult event for trivial reasons, having completely failed to register the significance of, for instance, the fact that an eerie glowing green train just pulled in at the station.
** In the season finale, there's a sequence where Dooley is traveling by himself, without [=McQueen=], and meets several sinister and/or supernatural creatures without noticing anything amiss, before encountering an innocent group of maintenance workers and jumping to the conclusion that they're agents of a sinister conspiracy.
** In the ChristmasEpisode, [=McQueen=] complains that Dooley has been playing Christmas music since Halloween, and Dooley thinks [=McQueen=]'s complaining that he didn't start sooner.
* In ''VideoGame/DuelSaviorDestiny'' when the principal learns that the local nun girl is actually the thief that dresses up like a stripper, her only comment is that her garb violates the school dress code.
* In a "Choose your own Nightmare" game called "The Evil Pen Pal", one ending has player character uses his new-found psychic powers to scare and lift said Evil Pen Pal up...and he's [[GoryDiscretionShot sucked into a jet-engine off-screen]]. The player character ''calmly says'', "Billy flew into the Jet Engine." to his brother when he asks what happened. His brother responds with, "Wow...cool...wanna go home?"
** This is heavily lampshaded in a LetsPlay.
--> "You can't ''DO'' that! You can't commit ''murder''!"
* ''VideoGame/FreddyPharkasFrontierPharmacist'': After [[spoiler:Penelope]] tells Freddy "it's always the person you least expect," Freddy starts rattling off all the people he suspected even less than [[spoiler:her]].
* Repeatedly in ''VideoGame/GhostTrick'', but the best example would be when [[PlayerCharacter Sissel]] goes to save someone from being executed. He arrives too late, and [[DeathIsCheap has to go back in time to prevent the man's death]]. Sissel, [[LaserGuidedAmnesia having no idea what an execution is]], offers up this utterly serious observation while watching events unfold:
-->'''Sissel:''' So this is an execution, huh? It seems to me there's gotta be a safer way to do it...
** Amusingly, he is also completely correct. The man's death happened when dust and faulty wiring on the electric chair caused it to ''explode'', destroying the entire room. It's just that Sissel, having no idea what any of this is, thinks this is the normal way of going about an execution.
* ''VideoGame/TheHouseOfTheDeadOverkill'' the Carnival level has one:
--->'''G''': (Sees an explosion in the distance) This is bad.\\
'''Isaac''': Damn right, this is bad! [[FelonyMisdemeanor You've seen the prices?!]]
* From the ''VideoGame/IWannaBeTheGuy'' offical FAQ:
-->'''''Q: [[SelectiveGravity APPLES DO NOT FALL UP]]'''''\\
''A: [[VoodooShark They're more like giant cherries...]]''
* In ''VideoGame/JollyRover'', James wonders why Melvin is smoking -- next to a large barrel of gunpowder:
-->'''Melvin:''' Capt'n Howell hates it too, says smokin's bad to ya health.
* One section of the AGD FanRemake of ''[[VideoGame/KingsQuestIIRomancingTheStones King's Quest II]]'' has Graham attempt to retrieve Neptune's trident from the King of the Sharkees, who's baffled by why he can't use its power. After all, the trident is enchanted in a way so it can only be used by those who possess "good will", and he with his sheer military might and ruthlessness obviously has ''the greatest'' will in the kingdom.
* In ''VideoGame/TheKingOfFighters XIII'', due to her extreme youth and PingPongNaivete, Kula Diamond often misunderstands what other people tell her in the pre-fight talks. HilarityEnsues every time this happens.
* In ''VideoGame/LunarEternalBlue'', TeamPet Ruby tries to explain to MysteriousWaif Lucia why she shouldn't [[InnocentFanserviceGirl go wandering around naked in front of Hiro and the other male party members:]]
-->'''Ruby:''' Nice girls don't show their no-no parts to boys until after they're married.\\
'''Lucia:''' You think Hiro and I should get married?
* The match commentators in ''VideoGame/MadWorld'' are only focused on the match about half the time. The rest leads to situations like this:
--> '''Kreese:''' [spends a minute recounting his fight with [[MsFanservice Elise]], the boss Jack is currently facing]\\
'''Howard:''' [[GagBoobs AWESOME RACK ON HER THOUGH!]]\\
'''Kreese:''' [[MaleGaze Aww, true dat!]]
* ''VideoGame/MassEffectAndromeda:'' On [[WretchedHive Kadara]], it's possible to find a corpse of an exile who had to go on the run because he borrowed some money from the local rulers. A datapad by his corpse has a recording of him moaning about the violent criminals wanting him to ''pay them back''.
* Philippine national hero Jose Rizal is an unlockable character in the multiplayer of one of the ''VideoGame/MedalOfHonor'' games, complete with rocket launcher. The game deliberately misses the point in the name of RuleOfFunny since in RealLife Rizal was a pacifist.
* In ''VideoGame/MetalGearSolid2SonsOfLiberty'' This is where the humour in the Otacon save calls during the Tanker chapter comes from. Otacon is trying to emulate Mei-Ling (from the first game) by giving Snake uplifting Chinese proverbs but he doesn't understand their meaning, so in trying to define their meaning he often totally misses the point. It gets to the point where Mei-Ling interrupts Otacon to tell Snake the real meaning of a proverb.
* Guybrush Threepwood of ''VideoGame/MonkeyIsland'' is prone to this [[DependingOnTheWriter depending on the player]]. In ''VideoGame/TheSecretOfMonkeyIsland'', for instance, Sheriff Fester Shinetop lures him into an alley and warns him that the area could be dangerous. One dialogue option has Guybrush ask if Fester heard something back there, too.
* Grobnar Gnomehands, resident SpoonyBard and {{Cloudcuckoolander}} of ''VideoGame/NeverwinterNights2'', is the ''king'' of this trope. One memorable incident has him meet [[VideoGame/NeverwinterNights the previous game's]] bard, the kobold Deekin Scalesinger. It's fairly well known in the D&D mythos that [[FantasticRacism kobolds hate gnomes]]. Deekin sings a piece of doggerel about butchering gnomes, and ''Grobnar turns into a music critic''.
* In ''VideoGame/DragonAgeII'', Merrill is regularly prone to this due to her innocence, [[LiteralMinded literal-mindedness]], and the fact that she [[FishOutOfWater doesn't quite get the finer points of the human culture]]:
-->'''Hawke''' ''(trying to bluff her/his way past the guards):'' There's a fire on the other side of this row! Get help before it spreads!\\
'''The guard:''' What?\\
'''Hawke:''' Don't you hear the screaming? Are you deaf?\\
'''Merrill:''' There's not really a fire, is there?\\
'''Hawke:''' No, Merrill, it's a trick.\\
'''Merrill:''' Oh, that was very clever then.\\
Cue to the guards attacking Hawke.
* ''VideoGame/PapersPlease'': On his second visit to your border inspection office, Jorji Costava attempts to pass through with a passport that's drawn ''in crayon'', but when you decline him entry, the reason you give him is "Cobrastan is not a real country." If you decide to let him through, the citation you receive will say the same thing.
* ''VideoGame/{{Portal}}'': A running gag with Aperture Science, especially [[VideoGame/{{Portal 2}} the second game]]. For instance, as you're about to burn to death, [=GLaDOS=] cheerfully reminds you that your gun is designed not to malfunction at high temperatures.
** The Investment Opportunity video for the Long Fall Boots reveals that they were invented to prevent ''the equipment'' from being damaged. This is demonstrated by showing the little cartoon scientists bearing a broken Portal Gun off on a stretcher while mechanical arms sweep the broken test subject into an incinerator.
** Also forms the entire basic premise. Aperture Science invented a working portal device in the 1950s... but never bothered to market it or even announce it to the public, because it was a failure as a shower curtain.
* There's many moments in ''VideoGame/PuyoPuyo'' of this, but one of the more notable ones is Klug telling Sig about bookworms, Sig loves bugs, and think the bookworm is a bug and will make his collection cooler, much to Klug's dismay.
* The "comedy" of Mcdougal's racism in VideoGame/RedDeadRedemption is that he tries to sound enlightened about how he discusses Native Americans, while failing to realize just how backwards his views are, to the point where he can't even draw a simple conclusion on why white blood and native blood are the exact same, ''even after that discovery refuted his own research.'' At one point, Native teammate Nastas makes a quip about how his people have been suffering ever since white men arrived, which lead to this magical exchange:
-->Mcdougal: It hasn't been easy for anyone, Nastas. Why, I knew a man in Yale whose father once shot 18 natives in one afternoon out in Wyoming. The man was quite, quite traumatized. He took to lying with choir boys.
-->[[TokenEnemyMinority Nastas:]] For a wise man, [[StupidScientist you are a very stupid man, mister.]]
* In ''VideoGame/RhythmHeaven Megamix'', the owner of the chameleon in "Tongue Lashing" sees his pet clinging to walls and thinks his lizard's getting stuck on them. To that end, the owner bought some wax and applied it to his chameleon's feet so that the chameleon will slide back down whenever he gets "stuck."
* ''VideoGame/ShadowHeartsCovenant'' has a hilarious example. Garan attempts to kill the party, however they're a bit more concerned about his appearance, at first. The final time he is encountered outside of a sidequest, he tries to scare the party by telling them that he sent them to hell. However, they all huddle and think that it's the pillow he's floating on. When he asks for their last words, Yuri says, "Yeah - that pillow. Where can I get one?"
* In ''VideoGame/Sly3HonorAmongThieves'':
--> '''Don Octavio:''' I know you're nothing without this little guy's brain. So I figure I'll scoop him out real slow and use him to fertlize my tomato plants.\\
'''Bentley:''' Oh no! I'm allergic to tomatoes!
* In ''VideoGame/SouthParkTheFracturedButWhole'', due to the hero being an HeroicMime, Cartman makes up a backstory for his superhero persona, where his life turning point was when he found his dad [[WhatDoYouMeanItsNotHeinous fucking his mom]]. Upon hearing this backstory [[OnlySaneMan Kyle]] berates Cartman about how all dads fuck moms. All of them.
--> '''Cartman:''' Oh right. So does that mean your dad fucked your mom, Kyle?! Huh?!
--> '''Kyle:''' YES! My dad fucked my mom! That's why I'M HERE.
--> '''Cartman:''' Dude, don't steal his backstory. That's not cool.
* WebAnimation/DotDotDot is a dramatic reading of a review for ''VideoGame/SuperPressSpaceToWinActionRPG2009'', written by someone who overlooked the fact that it's a DeconstructionGame.
* In ''VideoGame/TalesOfDestiny2'', Harold, the resident MadScientist, asks if she can dissect the most likely to die party member before (what they believe to be) the final confrontation with [[spoiler: Elraine.]] When she's told no one's going to die and thus that's not necessary, she asks whether she can ''vivisect'' someone instead.
* In ''VideoGame/TalesOfSymphonia'', Lloyd is relating stories of extrinsic motivation to [[{{Cloudcuckoolander}} Colette]] and Regal. Despite the fact that Regal CLEARLY tells Colette that Lloyd was referring to the temptation of the food that boosted his memories, Colette seems convinced that it was Dirk's cooking itself, and not the incentive of it, that taught Lloyd how to memorize the Dwarven Vows.
** Likewise, in the sequel, Tenebrae complains about the others thinking of him as a stick-in-the-mud. Colette tells Tenebrae that he has no mud on him, and that he shouldn't feel bad. After Emil tells her that, "there was never any real mud to begin with," Colette asks if it was more like a muck or a slime instead.
*** In another scene from the sequel everyone is guessing what the guardian of the tree looks like. Zelos guesses a hot woman (as is his nature), Presea and Regal hope that it has [[RunningGag paw pads]], Raine thinks it's a being like a centurion, and Marta just thinks it'll be old. Here's what Colette says:
----> '''Colette:''' So to sum up, the guardian is a wise old lady with a killer body and paw pads.
* In ''[[VideoGame/{{Touhou}} Phantasmagoria of Flower View]]'', quite a few characters miss the point of what Sikieiki's trying to tell them, even when Siki's being direct. Even Reimu and Marisa are guilty of this.
** In the manga ''[[AllThereInTheManual Wild and Horned Hermit]]'', Kasen Ibara puts up a sign saying "Only those who '''[[BoldInflation want to die]]''' should come here!" in an area filled with poisonous gases and infested with evil spirits. Reimu and Marisa take this literally, reasoning that ''everyone'' dies sooner or later, and cheerfully mine the area for [[GoldFever gold]] (which turns out to be made from the evil spirits's greed).
** Earlier in the same chapter has Kasen visiting Reimu's shrine, only to find it infested with vengeful spirits and Reimu missing. Then she notices a small gold nugget the spirits were swarming around...and immediately forgets everything about that, instead wondering how [[PerpetualPoverty Reimu]] got a hold of it.
* ''VideoGame/{{Undertale}}''[='=]s Papyrus is practically impossible for the player to insult; if you try to do so, he'll either think that you're just being {{Tsundere}} or that you're insulting ''yourself''.
* In ''VideoGame/WarioLandShakeIt'', one of the treasures Wario can find is an enormous emerald carved into the size and shape of a melon. His gluttony wins out over his greed, however, as he laments that it is not a real melon.
-->''Don't try to bite it--it'll only lead to heartbreak.''
* The Thraddash of ''VideoGame/StarControl'' have a civilizational cycle of one culture rising up, getting overthrown in a civil war that blasts the Thraddash some 500 years back, a new culture rising up, and so on and so forth (they're up to Culture 18 by now). Culture 14 warned about this 500-year setback, arguing that it really wasn't the best to handle things. The modern Thraddash insists this was proven wrong - the change to Culture 15 only set them back 200 years, maybe 300 tops.
* E. Honda from ''VideoGame/StreetFighterII'' onwards is characterized by his drive to establish greater respect outside of Japan for sumo wrestling. Thusly, he enters the World Warrior tournament to prove its legitimacy as a fighting style by winning the tournament. Except, to actually defeat his opponents, he makes use of numerous "alterations" to the style that would get him ''thrown out of a sumo ring for using them'', like headbutting and jumping. Even his willingness to fight outside of a traditional sumo wrestling ring is quite disgraceful from a traditionalist. In other words, E. Honda has only ''proven'' that sumo isn't a true fighting style... but he ''never'' figures this out.
* Beat from ''VideoGame/TheWorldEndsWithYou'' does this at the start of [[spoiler: the third week]].
--> '''Uzuki:''' You're treading on thin ice.
--> '''Beat:''' No I ain't. Shibuya's not cold enough for ice!