A list of characters of The Wire. This list will contain spoilers.
- Baltimore Police Departmentnote The Major Crimes Unit (James "Jimmy" McNulty, Cedric Daniels, Shakima "Kima" Greggs, Thomas "Herc" Hauk, Ellis Carver, Lester Freamon, Roland "Prez" Pryzbylewski, Leander Sydnor, Augustus Polk and Patrick Mahon, Caroline Massey), Police Commanders (William "Bill" Rawls, Ervin Burrell, Stanislaus Valchek, Commissioner Frazier, Raymond Foerster, Howard "Bunny" Colvin, Dennis Mello, Jimmy Asher, Charles Marimow), Homicide (Bunk Moreland, Jay Landsman, Michael Santangelo, Ray Cole, Edward Norris, Vernon Holley, Frank Barlow, Michael Crutchfield, Winona, Christeson), Others (Bobby Brown, Randall Friezer, Claude Diggins, Kenneth Dozerman, Anthony Colicchio, Eddie Walker, Brian Baker), Family Members of Police Officers (Cheryl, Marla Daniels, Elena McNulty, Shardene Innes, Michael and Sean McNulty)
- The Barksdale Organizationnote Leadership (Avon Barksdale, Russell "Stringer" Bell, D'Angelo Barksdale, Brianna Barksdale, Sean "Shamrock" McGinty), Soldiers and Dealers (Roland "Wee-Bey" Brice, Preston "Bodie" Broadus, Malik "Poot" Carr, Wallace, Marquis "Bird" Hilton, Anton "Stinkum" Artis, Savino Bratton, Wintell "Little Man" Royce, "Slim Charles", Dennis "Cutty" Wise, Sapper and Gerard, Country, Bernard, Chipper), Others (Wendell "Orlando" Blocker, Donette, Squeak, Devonne, De'londa Brice)
- Omar and Associatesnote Omar, Associates (Brandon Wright, John Bailey, Blind Butchie, Dante, Tosha Mitchell and Kimmy, Renaldo, Donnie), Omar's relatives ("No heart" Anthony Little, Josephine)
- Other Drug Dealersnote Prop Joe's Organization (Joseph "Proposition Joe" Stewart, Calvin "Cheese" Wagstaff, Drac), the Greeks ("The Greek", Spiros "Vondas" Vondopoulos, Sergei Malatov, George "Double G" Glekas, Eton Ben-Eleazer, "Sailor Sam"), the Stanfield Organization (Marlo Stanfield, Chris Partlow, Felicia "Snoop" Pearson, Monk Metcalf, Old Face Andre, Vinson, Little Kevin, Fruit), Other drug dealers (Ricardo "Fat-Face Rick" Hendrix, Nathaniel "Hungry Man" Manns, Kintel Williamson, Curtis "Lex" Anderson Pooh Blanchard)
- Downtown Charactersnote Courthouse (Rhonda "Ronnie" Pearlman, Daniel Phelan, Maurice Levy, Ilene Nathan, Gary DiPasquale, Rupert Bond), City Hall (R. Clayton "Clay" Davis, Thomas "Tommy" Carcetti, Clarence Royce, Coleman Parker, Norman Wilson, Nerese Campbell, Michael Steintorf, Andy Krawczyk, Odell Watkins, Theresa "Terry" D'Agostino, Anthony "Tony" Gray), The Baltimore Sun (Augustus "Gus" Haynes, Alma Gutierrez, Scott Templeton, Michael "Fletch" Fletcher, Thomas Klebanow, James Whiting)
- Other Charactersnote Homeless people and addicts (Reginald "Bubbles" Cousins, Johnny Weeks, Sherrod, Walon, Dee-Dee, Larry), The Docks (Beatrice "Beadie" Russell, Frank Sobotka, Nick Sobotka, Chester Karol "Ziggy" Sobotka, Louis Sobotka, Johnny "Fifty" Spamanto, Thomas "Horseface" Pakusa, Nat Coxson, Vernon "Ott" Motley, Maui), The Next Generation (Duquan "Dukie" Weems, Randy Wagstaff, Namond Brice, Michael Lee, Kenard, Donut), Other Characters (Terrance "Fitz" Fitzhugh, Brother Mouzone, The Deacon, David Parenti)