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Head of the CDC's rapid-response team, the Canary Project, Eph is a newly divorced father attempting to balance the custody battle over his son Zack with his duties as an epidemiologist. He and his Canary team are first-responders to the Boeing 777 disaster, and are tasked with solving the mystery of the mass casualty.
Eph's estranged wife and current opponent in a drawn-out custody battle over their only son.
The young son of Ephraim and Kelly.
The Vampire Hunters
Prof. Abraham Setrakian
A Romanian Jew who escaped the Treblinka extermination camp during the Second World War, Professor Setrakian has been a dedicated (and perhaps fanatic) vampire hunter for over six decades.
A skilled epidemiologist, Nora is second in command of the Canary Project. She and Eph have been attempting an office romance with mixed success, complicated by their high-stress medical careers and Goodweather's lingering melancholy over his looming divorce. Nora quickly dedicates herself to uncovering the vampire conspiracy, and is determined not to be relegated to doing the "woman's work".
An exterminator working for the New York City Bureau of Pest Control, Fet's occupation soon leads to his discovering the truth about vampires in a derelict building. Reaching Eph through a professional connection at the CDC, the exterminator lends both his skills as a vermin hunter and his powerful physique to Setrakian and Goodweather's cause.
One of the Ancients, the seven original vampires, the Master now inhabits the body of Jusef Sardu, a 19th century Polish nobleman afflicted with gigantism. While Sardu was a gentle giant in life, and greatly infirmed by his condition, the Master has imbued his form with unnatural power and ferocity. Breaking the territorial truce between himself and the other Ancients, the Master sets into motion a series of events to remake the world in his own dark image.
A handsome and charismatic shock rocker.
The former Nazi commandant of the Treblinka extermination camp.
Augustin "Gus" Elizalde
A Mexican gang member fresh out of juvenile hall, Gus is attacked by a newly turned vampire on the streets of Times Square, and is arrested by the police after throwing the creature under a truck. Learning the truth about vampires from a temporarily incarcerated Setrakian, Gus escapes confinement and finds himself to be a natural vampire slayer on the streets of his tenement neighborhood.
One of the richest men in the world, Eldritch Palmer craves the one thing that all his money cannot buy: immortality. The elderly tycoon's fear of death leads him to make a pact with the Master, trading his vast fortune, political influence, and the fate of the human race in exchange for an undead place at the vampire king's side.
Dr. Everett Barnes
As the Director of the Centers for Disease Control, Barnes is Eph and Nora's direct superior. Skilled in the politics and media aspects of the medical industry, he is a shrewd bureaucrat who carefully maintains a quaint, "country doctor" image.
A member of the CDC and assistant to Dr Goodweather.