This is for characters introduced in ''Anime/ResidentEvilDegeneration'' only. For characters in other games, go to their respective debut media.

* ''Characters/ResidentEvil1''[[labelnote:Introducing]]Chris Redfield, Jill Valentine, Barry Burton, Rebecca Chambers, Brad Vickers, Richard Aiken, Enrico Marini, Albert Wesker, Lisa Trevor[[/labelnote]]
* ''Characters/ResidentEvil2''[[labelnote:Introducing]]Leon Scott Kennedy, Claire Redfield, Ada Wong, Sherry Birkin, William Birkin, Annette Birkin, Brian Irons, Marvin Branagh, HUNK, T-00 (Mr. X), Tofu[[/labelnote]]
* ''Characters/ResidentEvil3Nemesis''[[labelnote:Introducing]]Carlos Oliviera, Nemesis T-Type (T-02), Nikolai Ginovaef[[/labelnote]]
* ''Characters/ResidentEvilGunSurvivor'' [[labelnote:Introducing]] Ark Thompson, Lott and Lilly Klein, Vincent Goldman, Andy Holland, Bruce McGivern, Fongling, and Morpheus D. Duvall[[/labelnote]]
* ''Characters/ResidentEvilCodeVeronica''[[labelnote:Introducing]]Steve Burnside, Albert Ashford, Alexia Ashford[[/labelnote]]
* ''Characters/ResidentEvil0''[[labelnote:Introducing]]Billy Coen, Dr. James Marcus[[/labelnote]]
* ''Characters/ResidentEvilOutbreak''[[labelnote:Introducing]]Kevin Ryman, Alyssa Ashcroft, Cindy Lennox, Mark Wilkins, David King, Jim Chapman, George Hamilton, Yoko Suzuki, Linda, Carter, Monica, Rita, Regan Mallet[[/labelnote]]
* ''Characters/ResidentEvil4''[[labelnote:Introducing]]Luis Sera, Ashley Graham, Ingrid Hunnigan, The Merchant, Osmund Saddler, Ramon Salazar, Jack Krauser, Bitores Mendez[[/labelnote]]
* ''Characters/ResidentEvilTheUmbrellaChronicles''[[labelnote:Introducing]]Colonel Sergei Vladimir, The Red Queen[[/labelnote]]
* ''Characters/ResidentEvil5''[[labelnote:Introducing]]Sheva Alomar, Josh Stone, Ozwell E. Spencer, Excella Gionne, Ricardo Irving, Alex Wesker[[/labelnote]]
* ''Characters/ResidentEvilTheDarksideChronicles''[[labelnote:Introducing]]Manuela Hidalgo[[/labelnote]]
* ''Characters/ResidentEvilRevelations''[[labelnote:Introducing]]Parker Luciani, Jessica Sherawat, Raymond Vester, Clive R. O'Brian, Quint Cetcham, Keith Lumley, Rachael, Morgan Lansdale, Jack Norman[[/labelnote]]
* ''Characters/ResidentEvilOperationRaccoonCity''[[labelnote:Introducing]]Vector, Spectre, Beltway, Bertha, Four-Eyes, Lupo, Umbrella Security Service Command, Crispin Jettingham (Callsign: DEE-AY), Erez Morris (Callsign: HARLEY), Lawrence Kimbala (Callsign: SHONA), Marisa Ronson (Callsign: TWEED), Carolyn Floyd (Callsign: WILLOW), Sienna Fowler (Callsign: PARTY GIRL), Government Spec Ops Command[[/labelnote]]
* ''Characters/ResidentEvil6''[[labelnote:Introducing]]Jake Muller, Helena Harper, Piers Nivans, Carla Radames, Derek Clifford Simmons, Ustanak, Haos, Agent, President Adam Benford[[/labelnote]]
* ''Characters/ResidentEvilDamnation''[[labelnote:Introducing]]Svetlana Belikova, "Buddy"/Alexander "Sasha" Kozachenko, JD[[/labelnote]]


[[folder: Senator Ron Davis]]

A US senator who has questionable connections to [=WilPharma=].

* [[spoiler:AssholeVictim: Tricell kills him for unknown reasons]].
* CorruptCorporateExecutive: Played with. Claire suspects him of this. [[spoiler:He's not]].
* DirtyCoward: Pushes Rani out of his way to escape from zombies, despite Leon placing his plan in action.
* EvenEvilHasStandards: He may have been selfish JerkAss who profited off of [=WilPharma=]'s dirty deeds, but he recoils in horror at Claire's accusation that he was the one who caused the outbreak.
* {{Jerkass}} ''Very''.
* TheLoad: One of the biggest in the whole franchise.


[[folder: Angela Miller]]
!!!Voiced by: Creator/LauraBailey

A female S.R.T. member sent to help rescue survivors at Harvardville Airport outbreak. Younger sister to Curtis Miller.
* FakeKillScare: [[spoiler: She puts a gun to Frederic's head. He begs for his life, but she pulls the trigger- it wasn't loaded.]]
* FauxActionGirl: Despite her qualifications, she doesn't actually contribute much to the fighting.
* GenreBlind: Despite being told how to deal with zombies, she runs over to help the first "survivor" she sees and moments later ''threatens'' to shoot an approaching crowd of zombies.
* GirlOfTheWeek: She and Leon seem to hit it off and part with vague plans to go "diving" together, but she's never mentioned again afterwards.
* HeroicSacrifice: Averted, but not for lack of trying on her part- Leon's sheer stubbornness prevented her from pulling it off.
* LeeroyJenkins: As a rookie police officer, she unhesitatingly jumped into raging rapids to save a child from drowning; she succeeded, but three other officers were injured fishing ''her'' out.
** Later on at the airport incident, after hearing several zombies moaning, she runs off while you have a guy who has much experience at handling zombies years prior.

[[folder: Frederic Downing]]
!!! Voiced by: Creator/CrispinFreeman
A [=WilPharma=] head researcher working to develop a cure for the T-Virus [[spoiler:so he can sell both]].

* [[spoiler:EvilBrit]]
* [[spoiler:DirtyCoward: Hilariously.]]
* CorruptCorporateExecutive: Subverted -- [=WilPharma=] is working with the T-Virus to make a cure. [[spoiler:Then double-subverted -- he plans to sell both virus and cure together to get more money.]]
* [[spoiler: ManBehindTheMan]]
* SilverFox

[[folder: Curtis Miller]]
!!!Voiced by: Creator/RogerCraigSmith

Angela Miller's brother. He injected himself with the G-Virus prior to the events of ''Degeneration''.

* CatchPhrase: "If you don't try to save one life, you'll never be able to save any". This ultimately haunted him.
* ThatManIsDead: After injecting himself with the G-Virus and going stage 2, Leon says "Curtis is dead".
* OneWingedAngel: Like William Birkin, except he doesn't have his face on the left side of his body and turn into a G-blob monster. Justified, as Leon manages to kill him before he could shift two more stages. Also to the fact that unlike Birkin, who succumbs to the G-Virus with every near-fatal injury, Curtis nevers goes beyond that due to his major injury against Leon never goes as far as Birkin's.
* TragicMonster: Unlike his predcessor who injected himself, killed his wife, and injected the G-embryo into his daughter, Curtis lost his wife and daughter. He presumably injected the G-Virus into himself, and nearly attempts to inject Angela with a G-embryo. He suffered a greater tragedy that he believes should be known to the world,
* WellIntentionedExtremist: Unusually for most Resident Evil villains, his motivations for doing evil was actually for benign reasons: He injected himself with the G-Virus and caused an outbreak in the [=WilPharma=] facility and at the airport in order to get them to reveal the truth of what happened in Raccoon City, as he didn't want the tragedy to ever happen again.