Here is the page detailing the specific characters that inhabit the world of Hana Yori Dango.
Makino TsukushiThe protagonist. A poor but extremely determined girl that wins a scholarship to Eitoku Academy. Originally, she tries not to stand out and ignores the bullying atmosphere despite her inclinations, but when her friends is threatened by the chief bully, she decides to dedicate herself to resisting it. The series focuses mostly on her romantic tribulations, first with the reserved Rui Hanazawa, then with the hot-blooded Tsukasa Domyoji who she ends up marrying. Voiced by Kelly Sheridan.
Domyoji TsukasaTsukushi's initial worst enemy. He starts out as a brutish, malevolent bully who is Tsukushi's main obstacle to happiness , then his attempts to harass her get less and less threatening and more and more amusing, and finally he becomes the main Love Interest. He's emotionally stunted, immature, and kind of an idiot, all of which get more sympathetic once you understand the incredible neglect that typified his childhood. The richest and most aggressive member of the F4, and therefore the leader. He has a definite soft side, especially when it comes to Tsukushi, but has an extremely gruff exterior.
Rui HanazawaThe closest that Tsukasa has to a best friend, and a member of the F4 as well. Tsukushi has a crush on him, since he has helped her out more than once. He's revealed to be still hung up on Shizuka, his childhood friend.
Akira MimasakaThird member of the F4, and a snarky playboy whose family belongs to the Yakuza in some continuities.
Soujiro NichikadoFourth member of the F4, he comes from a very traditional family involved in the tea ceremony business. Voiced by Andrew Francis.
Yuuki MatsuokaTsukushi's old friend, who works part-time with her in a dango shop. Voiced by Tabitha St. Germain.
Makiko EndouThe first friend that Tsukishi makes in Eitoku. It's thanks to Tsukushi standing up for her sake that she's at first targeted by the F4. Voiced by Nicole Bouma.
Shizuka TodouRui's girlfriend, a beautiful actress and teen idol. Voiced by Nicole Oliver.
Kazuya AoikeTsukushi's old friend, who arrives to Eitoku after his parents make it to the top of their business. Voiced by Brad Swaile.
Sakurako SanjouA really pretty girl whom Tsukushi protects from some people harassing her. However, she has a far darker side... Voiced by Rumi Shishido.
Kaede DoumyoujiTsukasa's mother, as well as the leaderess of the Doumyouji family. Voiced by Mika Doi.
Tsubaki DoumyoujiTsukasa's older sister, and the one who was mostly in charge of his early upbringing due to Parental Abandonment. A gorgeous and famous top model, she lives with her husband in the USA.
Shigeru OokawaharaTsukasa's very cute, yet also very eccentric fiancée.
Yuriko Asai, Minako Yamano, and Erika AyuharaThree girls who are INSANELY jealous of Tsukushi for the attention she gets from the F4.
Urara-senseiThe head nurse from Eitoku.