Voiced by: Susan Tyrrell
The main antagonist of "Darkness at Noon."
The main antagonist of "The True Face of a Monster."
- Anti-Villain: Type IV. The Golem was created to protect a Jewish synagogue from racist attackers.
- Guardian Entity: Created by a Jewish rabbi to protect a synagogue from anti-Semitic vandals.
- Healing Factor: The Golem could heal any wounds extremely fast.
- Super Strength: One of its powers.
The main antagonist of "Fear Itself."
- Harmless Villain: When the Ghostbusters finally confront it, it cowers in fear and does not fight back.
Crainiac, Corpuscle, and Gristle
The main antagonist of "Deadliners."
The main antagonist of "Casting the Runes."
Kahlil's minion. Appears in "Casting the Runes."
The main antagonist of "The Infernal Machine."
The main antagonists of "Killjoys."
- Monster Clown: They disguise themselves as clowns to get people to laugh so they can eat them alive.
- Our Vampires Are Different: Kylie surmises that they are a vampire analogy that feed on laughter instead of blood.
The main antagonist of "The Unseen."
Voiced by: Fernando Escandon
The main antagonist of "The Crawler."
Voiced by: Roger Rees
The main antagonist of "The Pied Piper of Manhattan."
- Humanoid Abomination: Until his true form is revealed, he looks indistinguishable from a normal human.
- Would Hurt a Child: He attempts to drown New York's children when the mayor refuses to give in to his demands.
Voiced by: Jonathan Harris
The main antagonist of "Be Careful What You Wish For."
- Hoist by His Own Petard: He is defeated when Kylie wishes that he doesn't grant her wish, the confusing nature of the paradoxical wish causing him to reveal his true form and become easy to trap.
- Literal Genie: Granted people's wishes in the literal sense. The results weren't pretty.
- Jackass Genie: It is implied that he knows exactly what his victims want, but twists the meanings of the wishes for his own sadistic pleasure.
The main antagonist of "The Jersey Devil Made Me Do It."
Dry Spell ghost
The main antagonist of "Dry Spell."
The main antagonist of "Sonic Youth."
Voiced by: Melissa Disney
Banshee's sister. Appears in "Darkness at Noon" and "Slimer's Sacrifice."
The main antagonist of "Ghost Apocalyptic Future."
The main antagonist of "Bird of Prey."
- Giant Flyer: The Harasvelg is a giant, bird-like creature.
The main antagonist of "Seeds of Destruction."
The main antagonist of "Luck of the Irish."
- Revenge: Seeks this on the descendants of those who imprisoned him in the first place.
- Sealed Evil in a Can: Thanks to a band of humans, one of whom was Mayor McShane's ancestor.
Voiced by: Glenn Shadix
The main antagonist of "The Ghostmakers."
of the Mirror Demon in "The Ghostmakers."
- Grand Theft Me: Their modus operandi. They kick people's souls out of their bodies and inhabit said bodies.
Appears in "Slimer's Sacrifice."
The main antagonist of "Slimer's Sacrifice."
The main antagonist of "Grundelesque."
Appears in "Grundelesque."
The main antagonist of "In Your Dreams."
- Hoist by His Own Petard: His plan to cross over into the real world through people's dreams would have worked if it weren't for the Ghostbusters immediately realizing that crossing over made him trappable and capturing him on the spot.
The main antagonist of "Moby Ghost."
- Sadly Mythtaken: The actual Ravana was a humanoid being with many heads rather than a cat-like demon who switched between fat and skinny forms.
- Villainous Glutton: He possesses people in a way that makes them devour food endlessly.
Oil Mine Ghost
Energy and Lightning Demons
The main antagonist of "Back in the Saddle, Part Two."
The main antagonist of "The Sphinx."
Voiced by: Ron Feinberg
The main antagonist of "Witchy Woman."