The episode, 'Gazpacho Stands Up', of Chowder has the main character scribbling on things in an effort to "improve his handwriting." After he scribbles on the camera lens, Gazpacho tells him not to draw there, after which the camera adjusts during Chowder's response to show the effect of the scene. Gazpacho then requests for the camera to come closer so he can clean it off. After cleaning it, Chowder points to the opposite corner of the camera, where the "Cartoon Network" logo is placed on broadcast shows. Gazpacho explains that he has tried to remove it, but that it won't come off.
The Sponge Bob Square Pants episode "No Free Rides" opens with Spongebob taking his driving test and driving right at the camera, knocking down the cameraman and startling the narrator.
In the Tiny Toon Adventures movie, Babs tests out her squirt gun on the camera. The cameraman then rubs his hand on the screen to dry it.
In "Homer vs. Lisa and the 8th Commandment" where Homer gets cable illegally, at the end, when Homer disconnects his illegal cable connection from the phone lines and ends with a static screen.
At the end of "Bye, Bye, Nerdie" where Lisa is menaced by a girl bully, when she goes on a punching spree in an auditorium full of scientists, ending with her jumping towards the camera with the screen turning black.
An episode of Ed, Edd n Eddy, "An Ed Is Born", goes to town with this one, with the majority of the episode taking place from a video camera's perspective, which Eddy is using to create a movie showing how much he's grown up to send to his older brother. Events include Ed's sister hitting the camera out of Edd's hands, Ed eating the camera (Complete with a view of his stomach) and the battery meter indicating that the power is about to run out.
Ed: Boy, I can't wait to see that part, Double-D! Edd: Yes, well, let's not and say we did, Ed.
Also used in the program's opening credits, when the Eds are posing for a photo and have to adjust the camera because their shenanigans have made it tip over.
This happens once in Teen Titans, where Speedy is wielding a nail gun, or similar device...and fires it like a machine gun by accident, leaving holes in the camera.
Henry and June on KaBlam!! do this many times, along with Prometheus and Bob.
In an episode of Popples, an errant baseball apparently fractures the glass on the viewer's TV set, almost literally Breaking the Fourth Wall.
Also, in "Moving Day", a pizza hits the screen.
A famous example happens in Tree House Capers. After the song "Row Your Boat", Party drops an anchor. Then, the baby Popples sit on the anchor and it goes very fast. Then, it breaks the screen. Then, PC blames Party for breaking the screen and she has to fix it. Clearly, she did not do it, the babies did it because they may be so chubby.
During W.I.T.C.H.'s first practice session with their new powers Hay Lin face-plants into the screen while flying around.
In one episode of Strawberry Shortcake's Berry Bitty Adventures, during a food fight, a piece of bread is flung toward the camera, completely covering the screen for a brief moment.
In another episode, a load of oranges overflow, covering the entire screen for a brief moment.
Pegasi at high speed sometimes cause this in My Little Pony: Friendship Is Magic, especially during 'Sonic Rainboom' as the Wonderbolts pass by the camera while diving at high speed. And then Rainbow Dash at even higher speed after catching them.
In The Smurfs episode "Reckless Smurfs", Snappy Smurfling throws a pie into the camera, covering the screen before it transitions to Gargamel chasing the Smurfs in his castle.
In Cranberry Christmas, the camera zooms in on the villain and gets a little too close, as the lens bumps into him, cracking it.
An Al Brodax Popeye cartoon dealing with a baseball game has Brutus hitting a foul ball into the camera so hard it shatters the screen of a TV set.