Being pushed around one too many times is listed as an example of common ways for espers to initially manifest their talents.
This is how Ian first manifested his telekinesis. Chad assaulted Ian at school and ended up getting hit with a TK Push strong enough to hospitalize him.
Lucky, who can start fires with his mind, is threatened by a liquor store clerk and chased by an entire angry mob.
Harry in Broken Things spends the bulk of the story being experimented on and tortured by Shop members who know that he's a powerful psychokinetic. See the page's Asshole Victim example to see how that works out for them.
Warlocks suffer an even worse treatment (due to their powers often but not always having a demonic origin) and Complete Arcane (the book introducing the class) points out how it should be standard for most settings to scorn, resent, and persecute warlocks. Given that warlocks are casters who have an unlimited store of spells (unlike the sorcerer, who will eventually run dry), and probably made a Deal with the Devil to get their powers (which, by the way, are far more focused on killing people than those of Wizards or Sorcerers), this really makes no sense.
There are also half-dragons, who are almost always treated badly by humans in Dungeons & Dragons. Yes, they think it's a good idea to pick on the person with claws and sharp teeth who can breathe dangerous substances and who has a parent that can level the town, and often will do so to protect or avenge his/her child. Eberron averts this by making the half-dragons considered abominations by the dragons. Furthermore, even in the core game a lot of dragons are lax parents even with their pureblood children and are even worse towards their half-breed spawn, making this kind of justifiable — there's no guarantee that their dragon parent will care — but not quite.
The Dragonblooded supplement has a short story at the beginning of the chapter on Spellscales in which the main character encounters a young spellscale girl being bullied by a mob of normal kids, and managing to cast a high-enough-level Sleep spell to knock out eight or ten at once.
Wizards and Psykers of Warhammer and Warhammer 40,000 respectively. The Wizards normally don't give a damn about what peasants think but soldiers love them, and psykers, well, their powers come from Chaos... Considering that psykers are incredibly vulnerable to Power Incontinence, Demonic Possession, and in more than a few occasions having their skull turned into a portal to allow The Legions of Hell to overrun the planet, this trope becomes even more ridiculous if treatment of them within the Imperium wasn't less "ostracism" and more "immediate execution."
In the Deathwatch supplement Honour the Chapter, The Black Templars' history in the Jericho Reach began with a Prelate-Imperialis named Nadab Saul trying to convince the Black Templars to join the nascent Achilus Crusade in the worst ways possible. He tried to browbeat and intimidate the Marshals instead of appealing to their sense of duty. Even as Battle-Brothers hauled him away, never to be seen again, he continued to spit invectives, condemning the entire Chapter as traitors.
After the First War for Armageddon against literal Legions of Hell was won, Grey Knights and the Inquisition decided that to avoid corruption, all population and military at the planet must be sterilized and worked to death in the labor camps. That didn't sit well with Chaotic Good Space Wolves chapter. The result is Months of Shame, minor civil war that cost Grey Knights and Inquisition a battle fleetworth of ships, a whole brotherhood worth of Grey Knights (this squabble cost them as much as entire war for Armageddon. Yep, one brotherhood lost almost all its members twice in a matter of months) and from now on, any and all inquisitional ships over Fenris are shot on sight.
Inquisitors might believe that they have the right to be bossy around Space Marine Chapter Masters. Then their bodies happen to be found in the Chapter Monastery, supposedly killed by an ork sniper.
Eldar tend to be guided by false prophecies and will attack vastly superior forces, while being very arrogant about it.
The Elder Land Wurm's flavor text: "Sometimes it's best to let sleeping dragons lie."
Played with via the card Slumbering Dragon, which can't attack or block until it's had several counters put onto it. It gets counters whenever something tries to attack its controller.
In Pathfinder, this mentality is actually something that hags seek in villages to foster their changeling offspring. See, changelings are essentially Cute Monster Girls who more or less fit the anime Cute Witch look. Hags need to perform a magical ritual in order to transform them into the hideously ugly and more powerful hag forms — but they can only do so if the changeling accepts the ritual. As a result, the hags strive to ensure that the families or villages they foster their spawn to will be sufficiently hostile to someone who isn't "normal" that, when the hag makes the offer to her daughter, the embittered changeling will gladly accept in hopes of using that power for revenge. Needless to say, when the new hag has been reborn, she usually pays back her tormentors in spades.
Although Aberrant pushes the inevitable apocalyptic nova vs. baseline war as something inherent in the novas' nature, in the actual metaplot, the war doesn't start until novas learn that Project Utopia, the Mutant Draft Board that ostensibly works to promote nova/human peace, has been sterilizing every nova it can get its hands on. The Reveal of this panics every non-affiliated nova, gives the Nova Supremacists Teragen a huge boost in credibility, and outrages every formerly loyal nova, making the Aberrant War directly the humans' fault.