In the season 6 finale of Bones ("Change in the Game"), at the beginning of the episode, Hodgins and Angela are eating at the diner. Angela is heavily pregnant and past her due date. Feeling a bit annoyed at this, she liberally douses her food (fries and soup) with habanero sauce because she says she heard spicy food can induce labor. When Hodgine remarks that she might be using a bit too much hot sauce, Angela replies " Oh, no, this isn't that hot." and starts eating happily. Hodgins shrugs, puts a splash of the sauce on his fries and takes a bite. Cue gasping, coughing, and calling out desperately for milk.
One Swedish Chef sketch on The Muppet Show has him making super-hot chili. He adds a pinch of spice and a touch of pepper sauce, then takes a taste. Smoke comes out of his ears, but he decides to go Up to Eleven by dumping the whole bowl of spice and basically pour out the whole bottle of pepper sauce. This time when he tastes, his hat is blown off as he faints.
The Observers in Fringe apparently have very little sense of taste. In one episode, an Observer has a rare roast beef sandwich covered in jalapeños, an entire shaker of pepper and most of a bottle of Tabasco sauce. In season 2, we see that Observers like to meet in an Indian restaurant and chow down on Naga Jolokia peppers.
One episode of Law & Order began in a trendy seafood restaurant where it was the custom for every diner to bring his own favorite brand of hot sauce. The victim's hot sauce had been spiked with cyanide.
In a Saturday Night Live sketch, a diner at a restaurant orders the "super hot" wings. The server tries to dissuade him, then brings a plate of wings, which the customer notes aren't that spicy at all. The server confesses that they're just the "mild" wings. The customer, by now annoyed, demands the "super hot," at which point the manager sits down with him, tries again to talk him out of it, and finally has him sign a waiver. As the customer is about to take the first bite, the frame freezes and a voice-over explains that he subsequently ran out of the restaurant shouting "Woo woo," shot up into the sky and exploded. In a final irony, he had in fact been served the "medium hot" recipe.
In the different series, Man v. Food has attempted 17 different "hot sauce food" challenges (wings, sandwiches, phaal, and a pizza). "Food" won 2 of them.
A burger has "the four horsemen" of the chilies on it: jalapeños, serrano, habanero, and the Bhut Jolokia (also called the Naga Jolokia).
A Man V. Food Nation episode in Tulsa had a pizza with two times the jalapenos and habeneros and a "death sauce" that mixes in Thai Sriracha hot sauce and Naga Bhut Jolokia ghost chili peppers.
In Roswell, the alien characters put Tabasco sauce on everything they eat, from hamburgers to chocolate cake. They prefer things to be a combination of "spicy and sweet".
In an episode of The Nanny, C.C. takes Fran to a sushi bar. When Fran assumes that wasabi is the same as regular mustard, she puts too much of it on one piece of sushi, and as you can expect, the results aren't pleasant. What's more, after she recovers from the initial shock, her voice briefly turns smooth (so it does not have Fran Drescher's familiar high-pitched nasal tone); apparently, the stuff was so strong, it forcibly cleared her nasal passages for a minute or two.
Thomas from Skins disposes of Johnny White by besting him in a chilli-eating contest. Johnny gingerly places a Naga Jolokia pepper (allegedly; that's what it says in the show, just go with it) on his tongue and carefully, painfully, swallows it whole. Thomas grabs a handful and happily chews away, noting that his family used to grow them in his garden back in the Congo. Johnny's attempt to repeat this feat... goes poorly.
The short-lived series Mann and Machine had an episode where Eve challenged a suspect to a chili pepper eating contest. The suspect was willing to confess to his crimes in exchange for some water after trying the habaneros. Eve, being a gynoid, was totally unaffected by the peppers.
The Food Network program Heat Seekers is all about this, with its hosts traveling around a city looking for the spiciest foods they can find. They run into the Jolokia variants nearly every single episode.
In Jessie, a bully steals one of Ravi's dragonfire pepper sandwiches. After one bite, he starts screaming in pain, crying that his tongue is melting. When Ravi eats a whole pepper without suffering the same fate, Luke asks him how he does it. Ravi responds "Where I come from, people sleep on beds of nails and walk on hot coals. This is nothing!"
This is what happens when Able Team try eating the food in Sri Lanka. It's even worse that night when the food comes out again, described by one team member as 'napalm shits'. Ironically that saves their lives, as a hit team tries to kill them when they're asleep in their beds, only to find all three awake and annoyed on the toilet.
Neelix on Star Trek: Voyager has made this on at least a few occasions. His recipe for Rodeo Red's Red-Hot Rootin' Tootin' Chili put at least three crewmen in Sickbay.
Bottom – The list of spices Richie reels off in his ‘Sprouts Mexicane’, to cover any “embarrassment” due the core ingredient being “frisky”. * Said ingredient were leftover from Christmas Dinner. They are now being served at a Hallowe’en Party.
Richie: Well it’s… sprouts, pinch of chili powder, jar of curry powder, hint of tobasco sauce – well, three bottles actually. Not so much a hint, more a Party Political Broadcast – and the secret ingredient: gunpowder!
In the The Almighty Johnsons episode "Man-Flu", Ingrid makes special extra-hot curry. Ty, who usually has no working sense of taste, loves it. Mike, on the other hand, is gasping for air after one bite.
In iZombie, zombies like Liv can only taste food if it's doused in anything spicy like hot sauce or wasabi. Liv gets a bottle of this as a present from her new boyfriend Lowell, who's also a zombie.
In one episode of The Red Green Show, Red mixes up a batch for a lodge barbecue. It consisted mostly of ketchup, with some various hot peppers thrown in and some other ingredients, including the "secret ingredient", which was some blue goop in an unlabelled container (later found out to be jet fuel). To demonstrate how hot it is, Dalton tastes a little bit on a toothpick and nearly doubles over in pain from the heat. Then Harold tastes a big spoonful...