A viral video showed a guy spoiling Harry Potter and the Half-Blood Prince to a bunch of Harry Potter fans waiting outside a bookstore for the novel. One fan's reaction is a woman at the end of the video yelling "NOOOOOOOOOO! You Bitch! YOU BITCH!!".
In a video featured on many cop shows, a man being arrested for possession of marijuana screams "NOOOOOOOOO! Please! God Almighty!" etc., a.k.a. the Crybaby Criminal.
This will happen quite a lot during hot blooded Left 4 Dead expert campaigns whenever the last player left alive after the second Tank dies gets tackled by a hunter feet away from the rescue vehicle.
Or when a user gets his righteous Karmic Retribution in the form of a Karma Charger or Karma Tank.
In 2004, a woman at a Dick Cheney rally was arrested and nearly charged for shouting five Big Nos in a row.
American senator Larry Craig shouted "NNNNNOOOOOOOOOO!" when the man he was propositioning for anonymous gay sex (by tapping his toes) in a Minneapolis airport bathroom revealed that he was a police officer. Later, he tried to claim that while he had been tapping his toes in the bathroom stall, he wasn't cruising — he simply had a "wide stance" while using the toilet. This created one of the world's most epic political memes, but convinced nobody — if his taps were completely innocent, why the Big No?
This man watching his football team losing a game that will result in the team falling out of the "A" league, big no is at 2:48 but you want to watch it all, it's hilarious. (it's in spanish unfortunately, there are subtitles that kind of suck but get the message across. Also, VERY NSFW, a lot of swearing and such). http://www.youtube.com/watch?v=SSZ3JVWDw4I
The YouTube user Hamster Alliance lets out a hilarious (and completely understandable) one during his playthrough of Super Meat Boy. He also tends to degenerate into sad "I want to give up" laughter and random bouts of frustrated gibberish.