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* ''Roleplay/DestroyTheGodmodder'' has a fairly obvious one. The Godmodder. This isn't completely the case in the second one, where some of the screwiness seems to have a little grounding outside of the Godmodder's influence, but everything in the first game was at least indirectly the Godmodder's fault.
* ''Roleplay/WeAreAllPokemonTrainers'':
** Missingno, also called The Anomaly and He Who Must Not Be Numbered.
** 'M in the Unova arc.
** [[BiggerBad Ardos]] in the Ranger Regions.
** Napoleon in the Alternate Timeline.
*** [[ThanatosGambit DAMN IT, NAPOLEON!!!]]
** Annoski during the Keystone arc.
** [[VideoGame/{{Fallout 1}} The Master]] and [=PEFeDOS=] during PMD-R.
** AU!Alduin in [=RtAU=].
** The Ghost Lord in Conquest.
** Cipher for Unova-2, Holon, and Orre.
* Dr. Rex of ''Roleplay/DinoAttackRPG''. [[spoiler:At least, until it gets [[HijackedByGanon Hijacked By Baron Typhonus]].]]
* ''Roleplay/OutpostDefenders'' has Clark, the leader of Cordis Die. Almost all of the events in the story are about taking him or one of his major minions down.
* ''Roleplay/PokemonRiseOfTheRockets'' started out with Sleight, the ultimate ruler of Team Rocket, as the primary Big Bad. As time has gone on, however, it has shifted to the point where John Ford can be considered the Big Bad of the entire conflict.
** That being said, there is almost always more than one Big Bad operating at a time, creating a continuous BigBadEnsemble across the story.
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