The Simpsons features many characters with a Berserk Button.
- Bart's position as Homer's Berserk Button actually got him institutionalized in an early episode. When taking a Rorschach test, he flew into an angry rage when one of the blots oddly resembled "The Boy".Marge: Doctor, if you just talk to him for 5 minutes without mentioning our son, Bart, you'd see how sane he is.
Doctor: You mean there really is a Bart!? Good Lord! - And if you lose a simple sport like Bart did in "The Boys of Bummer", RUN! RUN FAST. RUN FAR. It somehow weakens the dollar.
- And if Maggie is separated from her pacifier, may God have mercy on your soul.
- Do not bad-mouth Duff at Moe's, or beer in general. That's just asking for trouble.
- When Moe says "Put your beer on a coaster" he means it!
- Moe isn't a fan of Bart's prank calls, either. And as "New Kid on the Block" demonstrates, he will follow up on his threats, even if his sole intention is to scare the living daylights out of whoever's calling him. Strangely, though, he only reacts in the immediate aftermath of the call, as hints are dropped that he knew it was Bart all along.
- Badmouthing MacGyver around Patty & Selma is a sure fire way to get yourself killed (or something worse).
- Never take Barney Gumble's beer away from him or knock it out of his hand. He outright headbutted a whole crowd after someone accidentally made him spill his beer.
- Due to the countless instances of Superintendent Chalmers shouting "SKIN-ERRRRRR!!!" it wouldn't be beyond the pale to assume Seymour is his button.
- Homer Fan Boy Mike Wegman will lash out at anyone who insults his idol. This gets deconstructed as a Fatal Flaw for him as Marge kicks him out of the Simpson household (though not banned) for making Bart cry and Mr. Burns shoots him in the face, which could've killed him if it weren't for Burns' gun being old.
- The one episode wonder Frank Grimes is quite infamous for his Berserk Button. Generally, Homer's existence may count as one, but a good way to earn his wrath is to call him his despised nickname, "Grimey".
- Lisa tends to get upset and lash out (if she doesn't panic, as in "Kamp Krusty") whenever she receives something less than an A, even an A minus.
