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Daemon from the Tamers Forever Series could be the posterboy for this trope, a nigh unstoppable psychopath who is fuelled by his own hatred, often exploding into violent rages and laughing maniacally at the sight of others in pain.
Joe Dark from Clash of the Elements is a very prime example of this trope and this very trait of his is amplified immensely after he gains the Dark King's powers.
Similarly, in Inner Demons, after Twilight is consumed by her Queen persona, she becomes an extremely mentally unstable sociopath who switches between cold emotional detachment and blind fury at the drop of a hat. It gets to the point where she even decides to kill her brother when he rejects her advances.
And that's before her Villainous Breakdown. Afterwards, she's left constantly switching between laughing maniacally and sobbing (it's actually implied that's her true personality trying to resurface and being forced back down by the Queen), and on top of that she's decided that rather than ruling Equestria, she'll destroy it.
Nightmare Phobia, the Big Bad of the Chaos Verse (an official spinoff of the POV Series above) is this trope in spades. And it's not helped at all by the fact that the more powerful she becomes, the more her memory is corrupted, which in turn only fuels her insanity more.
A Growing Affection has the self-named Reaper of Shinobi. She thinks that anyone who uses chakra (herself included) is a demon, so her goal is to kill all ninjas and then kill herself. Over the years she has come to believe the backstory she fabricated for herself (that she is the sole survivor of the destruction of her village in the last war).
Several characters in You Got HaruhiRolled!. The fic follows canon in portraying Ryouko in this way, but in addition, Haruhi is occasionally Flanderized into this trope, such as when she threatens to kill Kyon's sister for dishonoring the SOS Brigade. Additionally, Sasaki usually functions as the Only Sane Woman of her group, but in the chapter where she finds a Death Note, she arguably out-crazies YagamiLight himself.note Though this is only implied, rather than outright stated.
Twilight Sparkle is the prime example in Pages of Harmony, though Rainbow Dash is definitely no slouch in that regard either. Twilight basically tortures and Mind Rapes her friends to extract their Elements, becoming increasingly deranged the further she goes down the road. Rainbow Dash, the first killed as a result of Twilight's actions, has her memory twisted and warped to the point where she cannibalizes herself as a result of no longer having Loyalty to even herself, and swears that she'll find a way to kill Twilight for what she did.
Utakata, a.k.a. Saiken the Slug, in Kitsune no Ken: Fist of the Fox, is this. In fact, before he underwent the training that gave birth to the Kyuushingai, he was a homeless man with serious psychotic issues, but he had the presence of mind to hide that fact from the doctors and scientists who worked on him and the other eight members of the group. The end result...
Utakata: They allowed a psychopath like me to be transformed into a SMART psychopath.
In Mega Man: Defender of the Human Race, Dr. Wily and several of his Robot Masters are this. Both Wily and Bass love the sound of screaming, and Splash Woman goes berserk after Roll attacks her and threatens to destroy the entire cavern to get rid of her enemies.
In Sunset Of Time, the Big Bad, Vesper Radiance. She's an insane psychopath who has personally murdered several characters already, attempted to kill even more, and her victims include her own parents out of revenge for putting her in an orphanage as a foal.