The songCease to Exist aka Pokey Means Business used in the battle against Giygas in the "Devil's Machine". It starts out like a throwback to traditional 8-bit RPG battle music, then unexpectedly erupts into something... unsettling.
And then a remix that throws away all restraint, culminating in the musical insanity the battle strove for.
The Giygas Battle Music that plays during his second form. Insanely creepy and way ahead of its time. It sounds like something from Silent Hill. Certainly not the kind of music you expect from a final boss fight in a JRPG.
Even moreso the music after you beat Giygas.
Seconded. Those death cries over the static set in musical tone were one of the most jaw-dropping death scenes of the generation.
For some 1950's rock 'n' roll goodness, you have a choice for the 'New Age Retro Hippie' battle theme from the first and second games, and 'Rock and Roll' (either 'Mild' or 'Spicy') from Mother 3.
Bound Together; "48 songs Nearly 3 hours of music 8 bonus songs including demos and alternate takes the VG Frequency radio show from October 29th which featured the debut of Bound Together." Download it and give it a listen, If you have any love for Earthbound, it will take you back.
Run, My Dog, Run! from Mother 3. It's basically the soundtrack to Boney's Crowning Moment of Awesome. Whether or not Boney is the most powerful character, that scene singlehandedly solidified his "Boney is awesome" status forever.
Speaking of Theme of Love, there is also the vocal version of the song which is sweet and heartrending no matter what language it's being sung in.
Fan remixes of Theme of Love are no slouches either. There's this localized version of it in English, with lyrics translated by the person behind the fan translation of Mother 3, Tomato, so you can be sure this English version of the song is really as accurate as it can be in the language without sounding too awkward.
Piggy Guys is so awesome that it received an epic remix that contains another song which SHOULD have been in Brawl.
Though they were basically a spinoff of the Runaway Five from Earthbound, DCMC was an in-game rock/jazz band that took a few of the best Crowning Music of Awesome candidates from the game and made them a million times more Awesome. For example, the "DCMC Theme," a remix of Duster's "Mind of a Thief" tune.
Fate and Serious from Mother 3. The way to combo these songs is pretty clever, too.
Natural Killer Cyborg. An amazing rockin' theme that assures the player they are going up against a massive super-robot, and it's even got a bit of 'Beat It' mixed in for extra awesomeness.
At the end of Mother 3, the most beautiful songs from the trilogy are reprised, including (surprisingly) the MOTHER 1 main theme. What makes it go into absolute Tear Jerker territory, though, is the reprise of Pollyanna, played as you take the boat ride to Porky's room. What makes it so sad is that Porky has crossed the Moral Event Horizon so many, MANY times, in such horrible ways, that you know there's no way he can have a happy ending, and also that you're surrounded by mementos from Earthbound: turns out he really did like Ness as a friend after all, huh?
Bon Voyage Amigo. Only a game like Mother 3 can make what's supposed to be the joyous occasion of completing your party, a Tear Jerker moment.
It Is Finished/It's Over, a remix of the Love Theme played at the climax of Mother 3 where The Masked Man AKA Claus finally comes to his senses and says one last goodbye and apologizes to Lucas before killing himself. It's... * sob* very sad. * sniff*
Gentle Rain, a very peaceful and soothing track. The Mother 3i remixed version combines this with a remix of Confusion, the music that plays when Flint finds out Hinawa has been killed in a not precisely tactful manner, perfectly conveying a sense of shock and loss.
The entire game kicks off with a little song called Fun Naming. It's a gentle, moving piece that helps welcome the player to the Mother 3 world.
And after that, this song accompanies a sweeping view over the Nowhere Islands.
The Attic's A Dungeon!? is pretty easily overlooked, playing in only one pretty short area, but that doesn't stop it from being an awesome beat.
Monkey's Delivery Service, though not as sad as the aforementioned music, is still damn hard to listen to without getting teary, as it embodies all the shit Fassad put Salsa through.
After going through a long adventure, seeing the ending, the "The End?" screen and its secret, you're treated to a roll call of the characters you met in the game, set to this awesome medley, appropriately called Curtain Call. The way it starts, you can almost hear an entire audience roaring with applause in your head.
LOG-O-TYPE, a grand, majestic theme that plays when the Mother 3 logo appears in the intro of the game. To quote a Youtube commenter, "The first time you heard this, you knew you were in for one hell of a game".