Kat and Ana's segment of WarioWare Inc.: Mega Microgame$ features cutesy nature microgames...that are played to an epic samurai-saga song while Kat and her dog storm a castle taken over by an evil skeleton samurai to save her sister and the prince/princess. Never has keeping a kitten dry and catching a plushie with a crane been so awesome.
Not to mention the cutscene you get after you win. Kat slicing apart Bonehead with the giant sword her dog turns into is freaking awesome, especially with the background music.
Ashley's boss game in Touched! is this. You play as the EARTH, dragging it around in space dodging COMETS and PLANETS SHOOTING BULLETS. Then, you rescue an astronaut (who nearly gets crushed by two giant asteroids), which gives the Earth the Moon that shoots LASERS. Then you fight and blow up a GIANT EVIL ALIEN PLANET THAT SHOOTS COMETS, all while SATURN is shooting bullets and JUPITER is shooting EXPLODING PLANETS. The whole time, awesome music is playing in the background.
The final boss battle game of Wario Ware: Smooth Moves, "Wario Dance Company", is the game's Crowning Moment of Crazy, with the player having to keep in time with three bizarre dancers. The first thing you do: whack your butt with the Wii remote.