* When Van Helsing tries to stake Dracula in the heart, it has no effect.
-->'''Dracula:''' (looks at stake, smiles) Hello, Gabriel.
* Despite being a gypsy princess who spent most of the movie needing to be rescued, when she's been kidnapped by the last of Dracula's brides and is about to be sucked, Anna redeems herself with this exchange.
-->'''Aleera:''' Anna, my love. It is your blood that shall keep me beautiful. What do you think of that?\\
[''laughs triumphantly, then screams as Anna catches a silver stake and impales her through the chest'']\\
'''Anna:''' I think if you're going to kill somebody, kill them! Don't stand around talking about it!
* The climactic werewolf vs vampire battle, especially the moment where [[spoiler:Werewolf!Van Helsing sharpens his claws on a metal surface and shows them to Dracula with a glare that means business.]]
* A flying vampire bride vs Van Helsing armed with an AutomaticCrossbow. Once it's been dipped in holy water, the fight becomes a whole lot shorter and one-sided.
* The reveal of Dracula's true castle.
* Frankenstein's Monster smashing in through a window, flattening the last of Dracula's brides as she's about to rip Anna's throat out, before holding her off to let Anna get to Van Helsing.
* Van Helsing's [[spoiler:transformation into a werewolf.]] Even Dracula was freaked out.
* In the animated prequel, Carl gets an awesome moment when he throws his holy water gun into a pit of hellfire, cleansing it and destroying the undead threatening them.
** He got a ''stealth'' [=MoA=] in the original film, by shoving the Bucharest party's fire-eater from behind, just enough that the unsuspecting performer set Dracula on fire. And did so discretely enough that Dracula apparently doesn't realize it's ''Carl's'' doing, but throws the fire-eater clear across the room for being so clumsy.
* The light bomb. At the very beginning of the movie, just before Van Helsing sets out for Transylvania, Carl tells him he's just finished it and what it does--it creates a blast of light equal to the intensity of the Sun itself--but doesn't know what they can really ''use'' it for. At the end of the second act, as literally ''hundreds'' of vampires are closing in on them at Dracula's summer home in Bucharest, they find out ''exactly'' what they can use it for. Cue dropping the bomb on the ground, which creates enough light to clearly shine out of ''every opening in the entire building'', and there's nothing left of the other vampires but bones.
--> '''Van Helsing:''' Carl! You're a genius!
--> '''Carl:''' A genius with access to unstable chemicals!