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Eliza fleeing across the broken ice field of the Ohio River, carrying her young son and chased by hounds. Based on a real incident, which inspired Stowe to write the novel.
Uncle Tom's Heroic Sacrifice of dying under Legree's whip for refusing to tell him where Cassie and Emmeline, two fleeing female slaves, had gotten. Even more so because Cassie actually asked Tom to escape with them, but he refused because he was already old and didn't want to be The Load.