The fact that Offred, whether she survived or not, was able to leave a record of her time in the Republic of Gilead. Even if know-it-all professors are skeptical of her accounts, she was able to reclaim something that Gilead took from women: a voice.
The Epilogue reveals a few things: that the Gilead regime had ended and a new world was brought up, one where women regained their rights e.g. Professor Maryann Crescent Moon.
Similarly, the names of the professors and their respective universities also imply that Native Americans/indigenous Canadians have regained power, and developing nations like India have survived. In short, non-white groups have survived and the white-supremacist Gilead regime has not.
In the movie: Kate/Offred ends up killing the Commander with Mayday later rescuing her. She was true to her word that no one would take her baby or control her, and the shots of the battle between Gilead and the Rebels is nothing short of amazing.
In the book and especially the TV series, Ofglen is extremely brave. No matter what happens, she's determined to go down swinging.
For the TV series
Offred spitting out the bite of the cookie Serena condescendingly gave her.
This exchange from the TV series, which leads to Offred being clubbed in the head and electrocuted.
Aunt Lydia: Remember your scripture; blessed are the meek.
Offred: "And blessed are those who suffer for the cause of righteousness for theirs is the kingdom of Heaven." I remember.
After Serena Joy banishes Offred to her room for more than thirteen days, Offred tries to suck up to Serena Joy to be let out. When this fails, Offred, after learning that her predecessor committed suicide, emotionally manipulates Fred, and succeeds. It's one of Offred's few personal victories, and Serena Joy can't do anything but glare at her as she goes out on her errands.
Offred carving her own message in the wall of her closet, indicating that she wants the next Handmaid, the next Offred, to remember her.
There's something subtly awesome about the fact that, in the TV series, we get to learn the Handmaid's names. No matter what the Commanders and Wives call them, these women are all individuals with their own stories and names, and Gilead can't take that from them.
In A Woman's Place, Offred makes the decision to tell the Mexican ambassador exactly how awful the life of a Handmaid in Gilead is, fully aware of the terrible risk she's taking, and under the belief that the ambassador's attendant may be a supporter of the Gilead regime. After all the effort Gilead goes through to take away women's voices (and the extremely unconvincing charade they've put up to downplay this fact in front of the ambassador,) Offred is at long last able to use that voice to undermine it.
Moira's escape from Jezebel's is fantastically uplifting, especially after seeing how defeated she seemed after reuniting with June.
On a day out, Emily finally has enough and races into a car. She's ordered out but instead starts it up and drives around, the first woman to do this in years. The crowd is shocked as the Handmaids watch, all clearly doing their best not to openly cheer Emily on.
When a soldier is knocked back, Emily stays in the car. She looks to Offred who gives the slightest nod. Emily proceeds to run the fallen officer over with the car, blood spraying everywhere. She's arrested but clearly is happy to have struck out at last.
Serena Joy's "The Reason You Suck" Speech to Fred, after she finds out about his secret meetings with Offred, whilst he blames her for his infidelities. She also doesn't hesitate to tell him that Offred's pregnant, but the baby isn't his and will never be due to his stupidity and sterility.
Offred telling off Serena Joy after Serena not only takes her to where her and Luke's daughter is being held and doesn't allow Offred to see her, but also threatens her life if anything happens to Offred's unborn child or if Offred steps out of line.
Offred: What is wrong with you? What is wrong with you? How can you do this? You're deranged. You're...you're...you're fucking evil. You know that? You are a goddamn motherfucking monster! Fucking heartless, sadistic, motherfucking evil CUNT! Fuck you, Serena! You are gonna burn in goddamn motherfucking hell, you crazy, evil bitch!
After Commander Putnam is brought forward to the Commanders for his extramarital affairs with Janine and promises to run away to Canada with Janine, which lead to her Bungled Suicide, one of them reveals to Commander Waterford and the others that Mrs. Putnam came forward and asked that he received the harshest punishment possible, which the viewer then discovers is that he gets his left hand surgically removed. It's grim, but it's also satisfying to know that even the Commanders can't always get away with their unspeakable behaviour.
When the Handmaids are commanded to stone Janine, none of them likes it. Led by Offred and likely inspired by the Second Oglen's outburst, they refuse to, despite being warned there will be punishment for this. And the handmaids' Power Walk afterward.
As Offred's being taken away by either The Eyes or Mayday, The Commander and Serena are losing their minds and constantly asking where their pregnant and abused Handmaid is being taken to, only to be ignored. Serena angrily confronts Offred, only to be met with a silent and defiant smirk. Offred has no idea if she's being saved or being punished, but after everything she's been through at the Waterford house, she's going with a smile on her face.
The Season 2 premiere has this little, glorious Call-Back: Serena Joy comes in to see June when she's getting a gynaecological exam, and angrily tells her not to screw around again. June, knowing she's nigh untouchable by Gilead and by her respective Wife, just snarls, "Don't get upset, Serena. It's bad for the baby," in a magnificent Ironic Echo to what Serena Joy had frostily told June during her powerless Freak Out! at the end of Season 1.
The final scene of the Season 2 premiere: After Nick comes through and helps June escape, she burns her handmaid clothes, cuts off her hair, and even slices off the top of her ear to get rid of the tag injected there. Throughout it all, Elizabeth Moss fully sells the weight of the liberation and we end with another narration describing all her physical attributes, ending with "I am free."
Emily watching as the Wife in the Colonies dies a slow death by her poison. She tells the Wife, no, she let women get raped and doesn't deserve forgiveness or compassion for that.
After Offred gets captured and sent back to the Waterfords and has her spirit crushed in numerous ways, eventually she throws herself out of a window in a suicide attempt. When she wakes in the hospital, she realizes her baby is still alive despite her attempt and heavy vaginal bleeding. Her baby’s will to live reinvigorates June’s fighting spirit and she promises to make sure her baby doesn’t grow up in Gilead.
At the end of "First Blood," Ofglen suicide bombs a meeting of the entire upper government of Gilead, just like the way they took out the American government by an armed coup.
Serena Joy takes control during her husband's absence to restore peace. She even asks for June's help in achieving this.
Newly energized by getting Serena on her side, June starts a chain of the Handmaids all telling each other their real names, the first small step that could lead to a whole revolution.
June savoring the feel of a pen, finally feeling that she can wield an amount of power over Gilead. The visual click is also a tribute to the late Ofglen.
Several from "Smart Power":
The Canadians in general for barely concealing their disgust at the visiting party from Gilead.
When the Waterfords arrive in Canada, the welcoming party includes Deputy Minister Kevin Mc Connell who pointedly notes he used to enjoy visiting the United States with his husband. Fred tries to dispel the awkwardness by saying that Gilead anticipates that tourism will be a key part of their economy and hopes they both will visit, to which Kevin counters, "When we feel welcome."
Serena is handed a schedule of activities that doesn't include any words, just pictures. A rather understated Take That! at how Gilead treats its women.
Serena speaks with Mark, an ambassador from the real American government. He offers her a better life outside of Gilead, and notes that scientists believe that the infertility crisis isn't because of female infertility, but because of male sterility, leading to this exchange:
Serena: I have a child on the way.
Mark: That's not your child.
Serena: You don't know what you're talking about.
Mark: I'm sorry. I meant no offense.
Serena: If you had done better research, you would know that I would never betray my country.
Luke taking a photograph of himself, June, and Hannah before Gilead and confronting Waterford. He's clearly ready to kill Waterford right on the spot for what he's done to June. Pity the police stopped him.
Luke: Hey, Waterford! Waterford! You fucking piece of shit! Waterford:Commander Waterford if you don't mind. And you are? Luke: Luke Bakole. You raped my wife.
Nick gets the Jezebel letters into Luke's hands during a negotiation with the Canadian government. He and Moira make them all public, resulting in a massive public outcry and the Canadians immediately cutting off the entire deal, with a member who's gay taking special pleasure in telling the Waterfords they're no longer welcome in the country. Then Moira gets off a parting shot by shoving a sign with her real name at them on their way out, leaving Fred greatly unsettled to know she successfully escaped.
Before Serena Joy leaves, a woman contemptuously tells her "I don't know how you live with yourself. It's sad, what they've done to you."
A small one for Janine who tells Isaac "suck my dick" after he keeps telling her to be quiet when she and June are talking. Unfortunately, it ends with her getting hit across the face but not bad for somebody who's been broken into accepting the Gilead regime.
"I know I should accept the reality of you being born here. But fuck that."
June finding the strength to parent Hannah when they're suddenly reunited for 10 minutes. Instead of becoming mad or upset when Hannah pulls away from her, June allows her to be angry and validates it. She tells Hannah to obey her new parents and enjoy her life while reminding her that she and Luke love her. Despite everything Gilead has put her through, June's maternal instincts are still intact.
The show practically sweeping the 2017 Emmys, winning 8 awards out of 13 nominations (across 11 categories), and taking every category it was up for on the main telecast. Further achievements included:
The show winning Best Drama Series in what was considered (at least according to odds at Gold Derby) to be a slight upset against Stranger Things, which had won 5 Emmys at the Creative Arts Ceremony (including Casting). Margaret Atwood herself joined the crew onstage for the Best Drama win, to great applause from the audience.
Elisabeth Moss finally (in the eyes of many) winning the Primteime Emmy after years of coming up short for Mad Men and Top of the Lake. Her wins for Drama Lead Actress and Drama Series were her 8th and 9th career nominations. In her acceptance speech, she thanked her mother for teaching her to be a "fucking badass".
Ann Dowd winning Supporting Actress for a Drama Series (another surprise, as the race was seen to be between Thandie Newton in Westworld and Millie Bobby Brown in Stranger Things), giving Dowd her first bit of industry recognition in over 30 years of work.
Reed Morano's victory for Drama Directing making her the first woman to win the category since Mimi Leder for ER in 1995.
Alexis Bledel's win for Drama Guest Actress helped to solidify the sense of She Really Can Act that had built around her performance. Additionally, it meant that the show had managed to take all three female acting prizes in the Drama categories.
Showrunner Bruce Miller finishing out the Drama Series speech by encouraging everyone to pursue further activism against things they see as wrong.
Miller: Go home. Get to work. We have a lot of things to fight for.