Otto: I see everything in this city! Everything! That is my power! And my responsibility— to watch over and JUDGE YOU ALL!
Jameson declining protection and actually saving Otto in issue 12.
The Lizard (With Curt Conners' mind) saving Jameson from the Scorpion.
Lizard: I am Curtisss Connersss. And I will never let the monstersss win again.
The events of Superior Spider-Man #14, aptly named "War on Shadowland," definitely qualify. As the Kingpin outlines his plan to take advantage of the power vacuum Otto has created in New York's criminal underworld through his actions as Spider-Man, Otto surprises Fisk by hacking his comm. system and calling him out. Understandibly pissed off, Fisk goes out to meet him with an army of Hand ninjas, all hellbent on making the Wall-Crawler pay for his insolence. What they find, instead is Otto waiting for them in a massive mech-suit with an army◊ of "Spiderlings" (his minions) armed to the teeth. Cue one hell of a onesided Curbstomp Battle on Shadowland, one that the Kingpin has no delusions of winning, and opts to fake his death and escape.
Kingpin (at the gates with his army): Spider-Man! You would dare show yourself, at the gates of my stronghold, at the very heart of my kingdom? Are you mad? What could you ever hope to accomplish here?
Cut to Otto and his army of mechs and Spiderlings.
What makes this moment even more awesome is, unlike most superhuman battles, it was a controlled, precise, clean operation, with literally no civilian casualties. Otto took every precaution to make sure the civilians were safe, deploying several tactical squads and around 300 spider-bots into the surrounding neighborhoods, even making preparations to erect forcefields around their homes. One of the bystanders even compared the moment to Bastille Day. When the dust settled, Otto and his army strode out of Shadowland with their heads held high, and (as far as they were concerned) the day saved.
SpOck: People of Hell's Kitchen, your nightmare is over. Shadowland is no more.
Civilian:He did it. We're free.
In the Age of Ultron tie-in, Otto has had only minutes back in his lab when Ultron's drones arrive. Plenty of time. He's modified his spider-bots to take the drones over, then make them do the same to their fellows, stealing Ultron's army for himself (briefly).
"Firewall failure. System failure. System — system — superior."
Creating an army of henchmen.
Telling ALL OF NEW YORK that Phil Urich is the Hobgoblin and asking them to find him.
In issue #19, The silhouette of Ghost Peter forcing his way back into his mind, after Otto focused too hard on Peter's memories.
Otto's epic calling-out of the Wrecking Crew in Superior Spider-Man Team-Up #5:
"Attention, imbeciles! That doesn't really narrow it down, does it? Attention, imbeciles known as the Wrecking Crew! I advise you to surrender, you foul-smelling, thick-necked morons... As you are outclassed in every conceivable way! But specifically in intellect and power! But, on the other hand, if you want a fight... Bring it on, you pansies."
In issue #24, Mary Jane finally confronts Peter over what's going on. When she finds out about the Venom symbiote, she sics the Avengers on him.
Ock:[fighting off the Venom symbiote] I'm—I'm— Ghost Peter: I'm Peter Parker! I'm back! And this is just the beginning! Because, I swear to you, I will be...--FREE!
Issue #28: Mary Jane playing the role of the Wild Card and screwing up the majority of the Goblin King's plans.
Issue #29: The Goblin King hitting Otto where it really hurts: Blowing up the old Octavius home, the lab where he was first created, the place where all of his old inventions are stored, the bottling plant he saved and the heart clinic the he and Cardiac worked with.
Goblin King: Why, see here, if it isn't Chez Octavius? The house where you grew up. Oh, that's the lab where you had your octopus-related accident. And here's The Boneyard... where the police have all of Octavius' greatest inventions under lock and key. Look! The bottling plant that you as Spider-Man saved all those people from being blown up and guess what? They're all pulling a night shift. And what's this? The H.E.A.R.T. Clinic, where you dedicated so much time to helping the sick. An impressive body of work, Otto. A legacy any man would be proud off. Boom. Boom. Boom. Boom. Aaaaaand boom. HAHAHAHAHAHAHAHAHAHAHAHAHAHAHA!
Ghost-Peter: I remember this. Parker, my old foe, was dying... Trapped in my frail, decaying form. I'd finally won. He couldn't reverse the process... But enough of a link existed that he could force me to relive his memories. W-wait. Not... Not "his" memories. My memories.
Otto Octavius/SpOck: STOP! I don't want this!
Ghost-Peter: I do. Every triumph. Every tragedy. The heartache... And the joy. Family. Friends. The adventure of it all. And the fun. My God, there was so much fun. And it's mine! The good and the bad. I built that. And I'm not surrendering one second of it. I'm taking it back! ALL OF IT!
Otto's Heroic Suicide, because the egomaniacal Master Planner, the man so arrogant that his only real motivation in life was to make sure the whole world would praise his genius, gives up his life to Peter in order to save the love of his life and the city. Ock may not have been the real Superior Spider-Man, but he truly surpassed his past self.