- In one story, Rat-Man was confronted by a robot specifically designed to kill superheroes that had already killed his mentor (and from which Rat-Man had escaped once). Rat-Man annihilated it by opening a book, an act that summoned Chuck Norris, who destroyed the robot with a roundhouse kick. None of the thousand of witnesses saw it coming save for Arcibaldo, who, seeing Rat-Man opening the book, realized that Rat-Man's claim of having never read a book in his life because every time he tried Chuck Norris appeared from nowhere to take him on an adventure was true.
- In issue #94, Valker said he classifies superheroes in two categories: the ones who (try and fail to) stop gunshots with their hands and the ones who think he won't shoot them. Later in the story he asks Rat-Man what of these two kinds of heroes he is, and Rat-Man replies "I'm of the kind you can't shoot". Classifying Rat-Man as the one who thinks he won't shoot, Valker reaches for his gun... And that's when he realizes Rat-Man stole it before he asked.
- Rat-Man versus Il Drago (a Shallow Parody of Goku from Dragon Ball Z). No one had ever succeeded in resisting more than a minute against him, or even scoring an hit. Rat-Man not only resists longer than anyone before (at one point Il Drago started hitting him with a rock and demanded he pleaded for mercy. Rat-Man didn't plea, the rock did), but even hit him square on the nose with a punch. That was when Il Drago prepared his ultimate attack, that would send the victim in another dimension so far that everyone would forget it, but also when Rat-Man had another moment of awesome (this one shared): The Man With The Spider Costume (a Spider-Man Expy), has recovered his will to fight (previously lost after getting mauled by Il Drago) by seeing Rat-Man, and so he first socked Il Drago in the face, and then caused the ultimate attack to hit the two of them. To complete the awesome, Il Drago was forgotten immediately, but The Man With The Spider Costume wasn't.
- The end of 299+1, the 300 parody. Rat-man pulled an Ephialtes (by accident and sheer stupidity). But then he comes back and makes a Last Stand, so epic that the Persians run and don't dare to attack with swords but use a Rain of Arrows (against a single man). He gets to not be left behind and joins the Spartans in the march for the afterlife.
Persian Soldier: God Dwarfy! (referencing Rat-Man stature)
Rat-Man: (spears him) Say hello to him.
- The last part of the Matrix parody. Rat-man actually mans up and (at least tries to) fights with the Mr. Smith Expy. And then, battered and defeated, comes up with this:
Sparks of comprehension flash before my eyes. And I begin to understand. I understand that disks and toilet paper can be used on one side only... (Why your disks are full of fingerprints?) I understand how babies are born... (Push, Madam!) And I understand what is my power. I don't fly. I don't break walls with a punch. I don't stop rocks with my mind. But every time everything seems lost, i come down here. Beyond all the masks. Beyond all the names... down... until I touch the bottom. Here lies the Rat-Man. Here I find the strength to climb back up. The strength to get up. The Rat-Man is out. And now, no one can stop him.
- Also, the beginning of his battle with the Smith expy is the only time ever he subverts his Catch Phrase (see main article for reference): "I flex my muscles and I'M FLYING!".
- In issue #25, Cinzia epically subverts the Or Are You Just Happy to See Me? trope against the Cat, the villainous seductress.
Cinzia: It was a gun.
- Issue 86 and 87. A Darker and Edgier mini-arc about Janus Walker, set a post-apocalyptic world Dream World, specifically Rat-man's subconscious. This "Walker" is Rat-man's memory of his adoptive father. Badass ensues.
Woman: How are you planning to enter Joba's fortress? It's as closed as a fist!"Walker": Look inside your closed fist. What do you see?Woman: [does so] It's dark.
- Some people like to look at my son's memories. They find it funny. They rummage in my bag, and they laugh. They have no respect for a father's feelings. Big ugly beasts. Fathers, I mean.
- During the I Vendicatopi story arc (started as a The Avengers Shallow Parody), Pope Benedict XVI fought the alien invasion to a standstill. Doubles as Crowning Moment of Funny due his use of Palpatine's lightsaber and trademark Force Lightning to do so.
- During the same story arc, Rat-Man, for discovering his childhood hero and costume inspiration Mr. Mouse (a Shallow Parody of Mickey Mouse) has created multiple generations of both superheroes and supervillains in the name of profit, is left on the roof of southern one of the Sister Towers (counterparts to the Twin Towers), that is promptly hit by a plane with the other Vendicatopi on board to Kill 'em All. With some prompting from the ghost of his mentor The Bat (the only other superhero who had ever opposed Mr. Mouse), Rat-Man takes the only way to safety to continue the battle... Namely jumping on the roof of the Northern Tower. It's promptly shot into Negated Moment of Awesome when the ghost points out the Northern Tower was on the other side, but without that idiotic error he would have reached it...
- Issue #99 is the Grand Finale (the series is slated to end with issue #100, but it will be a celebration issue). Its awesomeness, with the final defeat of Mr. Mouse, is beyond words.
- Also one for the author himself, for setting an hell of Sequel Hook as the answer to a question posed over a dozen issues earlier: in 2014 The Shadow will have Janus Valker's son as its avatar, and said son is Rat-Man himself.
- Another for the author: he managed to make a Tear Jerker of Mr. Mouse's death, with a parody of the Italian version of the Mickey Mouse March being sung.
- One for Mr. Mouse: he may have created multiple generations of superheroes and villains to profit from their adventures, but said creations include an alien invasion and the Rat-Man verse equivalent of Galactus.
- In the story arc telling how Rat-Man became the hero of the City With No Name, Brakko was about to be killed by Ending, a Mook possessed by the Shadow, when Rat-Man got the drop on the Mook and broke his neck. Roof Hopping on him from nowhere. While paraplegic and forced on a wheelchair he moved with a joystick and his mouth, because even his arms were paralyzed.
- After that, the Ending stood back up thanks to his possession... When he discovered the hard way why Rat-Man was paraplegic: he had rejected his will to be a hero, who had left him and became a gigantic and muscle-bound copy of Rat-Man who always tried to get back into him... And the gigantic Rat-Man was about to try and return into Rat-Man. Cue asskicking and Ludicrous Gibs. Immediately followed by Rat-Man accepting the call... And absorbing the giant Rat-Man into himself, reacquiring the use of his body.
- As it turns out, Ortolani lied (or changed his mind) about the series ending with issue #100. And in issue #102 we have something awesome beyond belief, when Rat-Man is being chased by Ending with the intention to bring him to his master to become the new host. Rat-Man cannot escape anymore, when someone chase away Ending. Who? Janus Valker, who, completing a Brick Joke set up earlier in the same issue, apologises for being late, but he couldn't find a place to park. Rat-Man, Ending and the Shadow itself didn't expect this to happen.
- The attempt to bust Valker out of hell worked, but Rat-Man got trapped behind, with the Shadow planning to make him its new host. Rat-Man did the impossible: he kept it out. The Shadow expected him to be that good, so it forced Rat-Man to fight his own shadow, something that had destroyed any and all superheroes who had managed to come to the Shadow's realm to fight it. Rat-Man not only resisted more than any other hero, he went won. In the end the Shadow managed to get a new host after finding a way to break him, but still it's impressive.
- The early three-parter "The Ripped Web"-"The Wrath of Cover-Man"-"Spider Hunt". Because it featured Rat-Man helping the real Fantastic Four... And not only the adventure is as awesome as the Fantastic Four demands without losing the humour, but Ortolani managed to not have to alter their identities in reprints.
- On a meta level, the story is this for Ortolani because it proved beyond doubt that he could write a complex and adventurous story if he wanted while still keeping it funny.
- After Valker is rescued from The Shadow to fight it, he dies. We are treated to a long Dying Dream, two Endings come to claim his body... And Valker kills them while still dead. His heartbeat only returns after strangling them with a hand each...