- MAD's parody of The Morton Downey Jr Show (Issue #286, April 1989), called "The Moron Downer Jr. Show" deserves a mention. In the end of the parody, the Pope himself visits the show to deliver a message. The comic ended with a full page splash of the Pope punching Morton in the teeth. Damn!
- Issue #533, edited by "Weird Al" Yankovic, with several articles written by him. Two of the biggest names in satire, together at last.
- On a meta level, issue #539 has something that many fans have been wanting for a long time: a front cover illustrated by Tom Richmond!
- Also on a meta level... in March 2016, Al Jaffee was honored by Guinness Book of World Records for being the longest continuously working cartoonist, having not stopped since 1942!
- Another meta-level awesome. Since they were classic EqualOpportunityOffenders, they incurred reams of lawsuits...and won most of them. The rulings in their favor could fill a small library when it comes to First Amendment protection of satire and parody.
- Adding to the above; the whole magazine started out of anger at censorship. The anti-comics hysteria of the 1950's led to the Comics Code, which put most forms of comics out of business and forces the handful of survivors to severely Bowdlerize their content. One of the casualties was Gaines's Tales from the Crypt, deemed too dark and corrupting. Queue him taking that same Black Comedy, and applying it to a protected medium of satire and parody, which allowed for him to fire shots he couldn't even get away when writing the Cryptkeeper.
- Bob the Builder OWNING Andrew W.K. in Destroy, Bob The Builder, Destroy is a good example.
- For a bonus, Andrew W.K is Adam Westing as himself.
- "Once Upon A Toon", no question. How does MAD celebrate Cartoon Network's 20th birthday? With a character from pretty much every classic show uniting once again! Including Johnny Bravo, Dexter, Samurai Jack, Blossom, even Numbuh 1, and most of the time Cartoon Network just pretended KND didn't exist!
- And why did they unite? To see who's behind Cartoon Network's downfall. Not to mention that Stu Sny-err...Dee Dee claimed that it was because they needed to make room for all new shows. And this aired the week of their 20th birthday. Biting-the-Hand Humor doesn't even BEGIN to describe this.
- Even better, Dee Dee's Overly Long Gag about showing a "sample" of MAD on a TV, in a recursive, matrioska-esque way further hammers down the point about how MAD's pop-cultural nature is the only way the characters could possibly have been acknowledged and gathered. As a Youtube commenter pointed out, this is 50% Biting-the-Hand Humor, and (much more subtly) 50% fan-trolling. And 100% awesome.
- Rio-A: Blu gains Green Lantern powers, and gives rings to other flightless birds (Mordecai, Big Bird, etc.) to save Jewel. Awesome way to kick off Season 2.
- The Fandom Nod in "My Little War Horse" with the cake that has "Go Bronies" on it, as well as getting Tara Strong to reprise her role as Twilight Sparkle.
- LinKong vs MechaThatcher. Heck of a way to start off season 4. Made even better with Linkong being voiced by Gilbert Gottfried.
- Speaking of starting off season four with a boom (or should we say, a sonic rainboom?), MAD co-aired that sketch with "Rainbow Dash and Bernstein, a definite CMOA for the brony community. While the Fandom Nod in "My Little War Horse" was awesome and the other sketches never made fun of it, this sketch centered around MLP's male community in a positive light. But this line shows MAD has done their research:
Rainbow Dash: ...I can show you how to be 20% cooler by being a brony!
- There's also the part where he was fighting dinosaurs.
President Linkong: Anybody ELSE have any "differing opinions"?
- Let's just say Linkong in general was an awesome sketch.
- Even in a MAD sketch (I Am Lorax, to be specific) Will Smith is still badass
- G.I.E.I. Joe. They actually train farm animals to fight KOBRA.
- George Washington with Dual Wield axes fighting cherry trees. Yes.
- "Animal vs Appliance" Especially when animal wins
- Lex Luthor brought his own cheering squad.
- ArThor rescuing Jane Donkey Kong style.
- In the X-Mentalist sketch, Wolverine get a nice Bait and Switch interrogation.
Wolverine: Look, bub... in the criminal justice system, the people are represented by two separate yet equally important groups. (SNIKT!) Right claws, (SNIKT!) and left claws.