Lady Macbeth, even for her time, was and is a pretty new take on a female's role in drama. Her first words are some of the most famous parts of the play. Not to mention she is pretty much the whole driving force behind the events of the play... even when those events are not particularly nice.
Banquo: [Looking to sky, talking to Fleance] It will rain tonight.
Act V, Scene V, in which Macbeth resolves to kill every last sonuvabitch who attacks Dunsinane, even if he dies trying...
Arm, arm and out! If this which he avouches does appear, There is no flying hence, nor tarrying here... Ring the alarum-bell! Blow wind, come wrack! At least we'll die with harness on our back.
Macbeth's last words:
I will not yield, To kiss the ground before young Malcolm's feet, And to be baited with the rabble's curse. Though Birnam wood be come to Dunsinane, And thou opposed, being of no woman born, Yet I will try the last. Before my body I throw my warlike shield. Lay on, Macduff, And damn'd be him that first cries, 'Hold, enough!'