! The magazine:
* MAD's parody of ''Series/TheMortonDowneyJrShow'' (Issue #286, April 1989), called "The Moron Downer Jr. Show" deserves a mention. In the end of the parody, the Pope himself visits the show to deliver a message. The comic ended with a full page splash of the Pope ''punching Morton in the teeth''. Damn!
* Issue #533, edited by Music/WeirdAlYankovic, with several articles written by him. Two of the biggest names in satire, together at last.
* On a meta level, issue #539 has something that many fans have been wanting for a long time: a ''front cover'' illustrated by Tom Richmond!
* Also on a meta level... in March 2016, Al Jaffee was honored by ''Guinness Book of World Records'' for being the longest continuously working cartoonist, having not stopped since ''1942''!
* Another meta-level awesome. Since they were classic [[EqualOpportunityOffender Equal Opportunity Offenders]], they incurred reams of lawsuits...and won most of them. The rulings in their favor could fill a small library when it comes to First Amendment protection of satire and parody.
* Adding to the above; the whole magazine started out of anger at censorship. The anti-comics hysteria of the 1950's led to the Comics Code, which put most forms of comics out of business and forces the handful of survivors to severely {{Bowdlerize}} their content. One of the casualties was Gaines's ''Tales from the Crypt'', deemed too dark and corrupting. Cue him taking that same BlackComedy, and applying it to a ''protected'' medium of satire and parody, which allowed for him to fire shots he couldn't even get away when writing the Cryptkeeper.
* During a company-wide vacation to the Dominican Republic, Bill Gaines discovered that there was only one subscriber in the entire country, and his subscription was going to expire that month. The entire Mad staff - artists, writers, editors, and Gaines himself piled into a bus and drove out to his house. Gaines knocked on the subscriber's door, and with the entire staff of the magazine looking on, presented him with a renewal notice.

! The cartoon:
* WesternAnimation/BobTheBuilder OWNING Andrew W.K. in ''Destroy, Bob The Builder, Destroy'' is a good example.
** For a bonus, Andrew W.K is AdamWesting as himself.
* "Once Upon A Toon", no question. How does MAD celebrate Cartoon Network's 20th birthday? With a character from pretty much every classic show uniting [[FusionFall once]] [[VideoGame/CartoonNetworkPunchTimeExplosion again]]! Including WesternAnimation/JohnnyBravo, WesternAnimation/{{Dexter|sLaboratory}}, WesternAnimation/SamuraiJack, [[WesternAnimation/ThePowerpuffGirls Blossom]], even [[WesternAnimation/CodenameKidsNextDoor Numbuh 1]], and most of the time Cartoon Network just pretended KND didn't exist!
** And why did they unite? [[NetworkDecay To see who's behind Cartoon Network's downfall]]. Not to mention that Stu Sny-err...[[WesternAnimation/DextersLaboratory Dee Dee]] claimed that it was because they needed to make room for all new shows. And this aired the week of their 20th birthday. BitingTheHandHumor doesn't even BEGIN to describe this.
** Even better, Dee Dee's OverlyLongGag about showing a "sample" of ''MAD'' [[FramingDevice on a TV]], in a recursive, matrioska-esque way further hammers down the point about how MAD's pop-cultural nature is the only way the characters could possibly have been [[NetworkToTheRescue acknowledged]] and [[ReunionShow gathered.]] As a Youtube commenter pointed out, this is 50% BitingTheHandHumor, and (much more subtly) 50% [[TrollingCreator fan-trolling]]. And 100% awesome.
* Rio-A: Blu gains Green Lantern powers, and gives rings to other flightless birds (Mordecai, Big Bird, etc.) to save Jewel. Awesome way to kick off Season 2.
** When the BigBad tries to point out that Green Lantern rings don't work on yellow, [[MundaneSolution Mordecai just punches him in the face]]. Awesome.
* The Fandom Nod in "My Little War Horse" with the cake that has "Go Bronies" on it, as well as getting Creator/TaraStrong to reprise her role as Twilight Sparkle.
* [[Film/{{Lincoln}} Lin]][[Film/KingKong Kong]] vs [[WesternAnimation/TheIronGiant Mecha]][[Film/TheIronLady Thatcher]]. Heck of a way to start off season 4. Made even better with Linkong being voiced by ''Creator/GilbertGottfried''.
* Speaking of starting off season four with a boom (or should we say, a sonic rainboom?), MAD co-aired that sketch with "[[WesternAnimation/MyLittlePonyFriendshipIsMagic Rainbow Dash]] [[Series/CrashAndBernstein and Bernstein,]] a definite CMOA for the brony community. While the FandomNod in "My Little War Horse" was awesome and the other sketches never made fun of it, this sketch ''centered'' around MLP's [[PeripheryDemographic male community]] in a positive light. But this line shows MAD has done their research:
--> '''Rainbow Dash:''' ...I can show you how to be [[Memes/MyLittlePonyFriendshipIsMagic 20% cooler]] by being a brony!
* There's also the part where he was fighting dinosaurs.
-->'''President Linkong:''' [[BringIt Anybody ELSE have any "differing opinions"?]]
:: Let's just say Linkong in general was an awesome sketch.
* Even in a MAD sketch ([[Film/IAmLegend I Am]] [[WesternAnimation/TheLorax Lorax]], to be specific) Creator/WillSmith is still badass
-->'''[[spoiler: Zombie Lorax]]:''' The creatures of the forest seek revenge!\\
'''Will Smith:''' Well they can revenge on ''this!''\\
''[takes a shotgun and blasts [[spoiler: zombie versions of [[WesternAnimation/RegularShow Mordecai and Rigby]], [[WesternAnimation/TheLooneyTunesShow Buggs and Daffy]], and [[WesternAnimation/ThePowerpuffGirls Mojo Jojo]]]]]''
* ''G.I.E.I. Joe''. They actually train ''farm animals'' to fight KOBRA.
* UsefulNotes/GeorgeWashington with DualWield axes fighting cherry trees. Yes.
* "Animal vs Appliance" Especially when animal wins
* ComicBook/LexLuthor brought [[LegionOfDoom his own cheering squad]].
* [[Film/{{Arthur}} Ar]]Film/{{Thor}} rescuing Jane ''DonkeyKong'' style.
* In the [[ComicBook/XMen X-]][[Series/TheMentalist Mentalist]] sketch, Wolverine get a nice BaitAndSwitch interrogation.
-->'''Wolverine:''' Look, bub... [[Franchise/LawAndOrder in the criminal justice system, the people are represented by two separate yet equally important groups]]. (''SNIKT!'') Right claws, (''SNIKT!'') and left claws.