In 2006, she became the first female cast member to come back and host Saturday Night Live. It doesn't seem like much now (considering that Tina Fey, Amy Poehler, and Maya Rudolph have done it), but, prior to that, the only former cast members who came back and host were men (not even Joan Cusack, who actually found fame in the movies after her short-lived stint on SNL, came back to host) and Gilda Radner was scheduled to host in the late 1980s, but the show she would have hosted was canceled because of the 1988 Writers Guild strike and, what's worse, Radner died from complications of ovarian cancer on the same day Steve Martin hosted the last episode of the 14th season.
In 2010, she became the first cast member from Seinfeld to get a star on the Hollywood Walk of Fame.
In 2012, she became the 2nd actress in history to win Emmys as a main cast member on 3 different shows, following Tyne Daly. She managed to win for Seinfeld, The New Adventures of Old Christine, and Veep.
She is the current record holder for the most Emmy wins for a single character, comedy or drama, with six for Veep.
Using her breast cancer diagnosis not to garner sympathy, but support for universal health care.
Her attached message to her first publicly shared post-chemo picture: "Hey cancer: Fuck you!"