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Analysis: Sitcom Arch-Nemesis

This character is almost never one of the main cast. Exceptions to that rule include Mimi, Drew's nemesis from The Drew Carey Show, who is the second main character of the series; and Marcy from Married... with Children, who started out as just an ultra-nice neighbour but wound up as Al's cackling nemesis. An all-purpose jerkass along the lines of Frank Burns from Mash doesn't count, since he's hated by everyone equally.