!!General Examples:
* Creator/SidAndMartyKrofftProductions are notorious for using this trope (''Series/HRPufnstuf'', ''Series/{{Lidsville}}'', ''Series/LandOfTheLost'', ''series/TheLostSaucer'', ''Series/FarOutSpaceNuts'').
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!!Specific Examples:
* ''Series/BabylonFive'':
** In the episode "No Surrender, No Retreat", Mr. Garibaldi leaves the station knowing that with what he's a bout to do, he most likely will not be able to return.
** At the end of the final season, G'Kar finds he is unable to go home to Narn and cannot stay on the station because of his [[GroupieBrigade devout followers]] and so resolves to fly off into space. He takes Lyta Alexander with him, who notes that he has to leave because everyone wants him, while she has to leave because no one wants her. [[spoiler:Her powers have grown to the point that she's considered a threat by just about everyone.]]
* ''Battlestar Galactica'' (both [[Series/BattlestarGalacticaClassic old]] and [[Series/BattlestarGalacticaReimagined new]]):
** The writers combined this with a DoomedHometown to form the series premise. In addition, the fifth episode of the re-imagining's first season is called "You Can't Go Home Again", and involves Kara Thrace attempting to escape a barren planet to return to the Galactica, which (surprise, surprise) she does manage to do at the end, by using a crashed Cylon fighter to get off the planet.
** Oddly enough, throughout the first and second seasons of the new ''Battlestar Galactica'', numerous characters ''did'' go back home. Most notable case was Kara Thrace who literally returned to her (mostly undamaged) flat in Delphi.
* ''Series/BreakingBad'': Walter White is forced to go into hiding after [[spoiler:his family leaves him and the police are after him for being a drug kingpin]].
* ''Series/BuckRogersInTheTwentyFifthCentury'': Captain Buck Rogers really can't go back home because a) he's been gone for over 500 years and the neighborhood has [[SarcasmMode changed a little in the time since]] and b) a nuclear war effectively wiped out 90% of the world he knew.
* ''Series/DoctorWho'':
** The Doctor is unable to return to his home world of late, ever since it kind of got destroyed.
** In the old series, where the Doctor couldn't reliably control the TARDIS, most of his companions couldn't go home until it randomly ended up back in their home place and time again. Most of them didn't mind so much, but there were a couple of plot arcs in which the Doctor was actively trying to get a character home, invariably without success; variations included "exactly the right place, but three centuries early" ("The Visitation"), "exactly the right time, but several light-years away" ("Four to Doomsday"), "the right place ''and'' the right time, but due to a technical fault we're all only an inch tall" ("Planet of Giants"), and "the right place and time, but the wrong ''universe''" ("Full Circle"), not to mention the ever-popular "despite the Doctor's confidence that he's succeeded at last, both the wrong place ''and'' the wrong time" ("The Reign of Terror", ''passim'').
** However, the only companion who could truly never go home again was Nyssa, whose home planet was destroyed as a result of one of the Master's schemes.
** Also in the old series, the Doctor couldn't return to Gallifrey because interfering in the histories of other planets was considered a heinous crime. When he was forced to reveal his location to them ("The War Games"), the Time Lords captured, tried and exiled him.
* ''Series/{{Farscape}}'': John Crichton. Eventually he does make his way home, but he can't stay because he's changed too much... among other things, he's ''killed'', a ''lot''. While he's there, though, [[spoiler:an assassin tortures and kills his best friends, and wrecks his family's house]]. ''On Christmas''. Later, after he leaves, [[spoiler:he's forced to close the wormhole for good, to protect Earth from the Scarrans.]]
* ''Series/{{Firefly}}'': Neither River nor Simon Tam can return to their home on Osiris, because doing so would get Simon arrested and River sent back to the Academy. On a more blunt note, Malcolm Reynolds can't go back to his home on Shadow because the Alliance virtually destroyed the planet during the Unification War, rendering it uninhabitable.
* ''Series/GilligansIsland'' was a comedy example. Until "Rescue from Gilligan's Island", where the castaways become [[StrangerinAFamiliarLand strangers in a familiar land]].
* ''Series/HighlanderTheSeries'':
** Duncan [=MacLeod=] is banished from his Clan after he resurrects for the first time.
** This happens to most Immortals. Once people notice that they are not aging they will have to move away and can only really come back when most of the people who used to know them are dead. This is also required when an Immortal 'dies' in public and thus risks revealing TheMasquerade if he/she does not leave.
* ''Series/LastResort'': The whole premise was that the crew of the ''Colorado'' could never return to the United States, because they had been portrayed as traitors after refusing to nuke Pakistan. [[spoiler:Of course, the series' cancellation only halfway into its first season caused the writers to come up with an overly complicated way around this premise, so that only the Captain and those who had died during the course of the season were denied the ability to return...]]
* ''Series/LifeOnMars2006'':
** Likewise. Sam finally returns from the grey-brown-orange world of 1973 and decides that the modern world lacks colour.
** And in the spin-off, [[spoiler:Alex Drake discovers that she can't return to 2008, because she is dead]].
* ''Series/{{Lost}}'': Part of the premise. [[spoiler:SubvertedTrope in the third season finale, when they finally ''do'' get to go home, only to have Jack convinced it was a big mistake to leave]].
* ''Series/LostInSpace'': Series premise.
* ''Series/MythQuest'': Matt Bellows touches the Gorgos stone in the Cyber Museum, which causes him to get stuck in a world of myriad mythologies. He could only get out of the myth-world by touching the stone again, but he doesn't know where it is.
* ''Series/QuantumLeap'': In which not only can Sam Becket not go home, he can't even stay where he is, and must live moments from other people's lives, his leaps inevitable, finding himself in a new stranger's shoes each time.
* ''Series/RedDwarf'': The key premise. Protagonist Lister awakes from what was supposed to be eighteen months in stasis, but was actually three million years. He is the last living human on his ship. He sets off to see whether he's the last living human in the universe. HilarityEnsues; signs of what became of Earth humans does not. (Though in the books, we do have them reach Earth... and it was used as a garbage planet until an explosion sent it out of orbit. The current residents are sentient roaches who don't know a thing about those ape people there used to be.)
* ''Series/{{Revolution}}'':
** When you think about it, the world got a blackout that is still in effect 15 years later. The United States is effectively dead. Even if the power gets turned back, [[spoiler: which happens in the [[Recap/RevolutionS1E20TheDarkTower first season finale]]]], things are not going to go back to the way they were before the blackout!
** Rachel has to point this to Aaron more or less at the beginning of [[Recap/RevolutionS1E11TheStand episode 11]]. In that same episode, [[spoiler: Jason Neville]] is told to not even bother going home again by his own father.
** In [[Recap/RevolutionS1E13TheSongRemainsTheSame episode 13]], Neville tells his wife this after [[spoiler: his mission to obtain the nuke for Monroe fails]] and he realizes that thanks to Randall's influence his days in the Republic are numbered.
* ''Series/{{Sliders}}'':
** For the entire run. The writers eventually combined this with DoomedHometown in order to give the series a BigBad.
** Although one episode ended with the heroes briefly (a few minutes) ending up in a world that looked a lot like theirs, but were disappointed when Quinn sadly noted that the fence gate at his home didn't squeak, as it did in their world, so they jumped into the next vortex that appeared. But after it vanished, a local guy came out of the house with Quinn's mother and mentioned that he'd finally fixed the squeaky gate hinges.
* ''Series/StargateAtlantis'': The entire cast in the first season. That concept was quickly destroyed.
* ''Series/StargateSG1'':
** Teal'c's MookFaceTurn in the pilot resulted in him and his family being branded as traitors; returning overtly to Chulak as long as Apophis rules there is suicide. [[spoiler:This changes over the course of the next three seasons.]]
** An episode called "A Hundred Days" plays with this trope. A meteor shower during a mission strikes the Stargate, burying it and leaving O'Neill stuck on an alien planet, with the rest of SG-1 having made it back to Earth. O'Neill spends the following months trying to find the gate, hoping that rescue will come. As he finally gives up on the idea of traveling through the stars and going back to Earth, he begins to make a life for himself with the people still on the planet with him. That is until his 100th day there when SG-1 finds a way to make contact with the gate and dig it out. O'Neill's having to choose between his new life and his old one is something of a TearJerker.
** Martin Lloyd, the creator of ''[[ShowWithinAShow Wormhole X-treme!]]'', [[spoiler:is one of the five known survivors of a spacefaring people that was destroyed by the Goa'uld. The only reason they're alive is that they deserted their homeworld's military]].
* ''Series/StargateUniverse'': The basic premise. Apparently wanting to avoid the problems of the previous one, they've stranded the crew so far out that it would literally take decades for a current generation ship to catch up. They can make short trips home using the [[GrandTheftMe communications stones]], but such trips are temporary and don't solve the supply-line issues.
* ''Series/StarTrekDeepSpaceNine'': Garak was exiled from Cardassia [[spoiler:and is only permitted to return after the entire planet has been carpet bombed]].
* ''Series/StarTrekVoyager'':
** Series premise. In the premiere, the ship winds up on the far side of the galaxy. Their journey home by the linear route (even at warp speed) would take at least 70 years, or more than most of the crew's lifetime. They use alternate technologies and wormholes to significantly reduce the time it actually does take but this was still the situation they were facing at the start of the series.
** This is especially true for Neelix, whose homeworld was destroyed, and Icheb, whose parents want only to use him as a weapon.
** One exception to this is the Doctor; he's the ship's Emergency Medical Hologram, so ''Voyager'' '''is''' his home.
** It is mentioned that even if Kes returned to the Ocampa homeworld, they would no longer accept her.
* ''Series/{{Torchwood}}'': [[FishOutOfTemporalWater Jack Harkness.]] Not that he'd want to go back, apparently (going by the conversation with Ianto in "To the Last Man.")
* ''Series/{{Supernatural}}'':
** In the episode [[Recap/SupernaturalS02E20WhatIsAndWhatShouldNeverBe "What Is And What Should Never Be" (S02, Ep20)]], Dean returns to his childhood home and his mother is still alive. However, this was just an illusion created by a djinn, and Dean's childhood home was destroyed in a fire which killed his mother and started his nomadic lifestyle.
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