* BestKnownForTheFanservice: The most known scene of the film is when Sally fakes an orgasm in a crowded restaurant -- possibly approaching AllThereIsToKnowAboutTheCryingGame.
* FamilyUnfriendlyAesop: Men and women can never be just friends. Also increasingly a case of ValuesDissonance as people of both genders become more integrated.
** Averted as Harry and Sally were friends for a long time before falling in love. It also proves Harry's assertions wrong, as he's friends with Sally because they are genuine good friends, and he does not show any signs of wanting to have sex with her during their friendship, and only barely when he falls in love with her.
* HilariousInHindsight: Harry is seen reading ''Literature/{{Misery}}'' by Creator/StephenKing. Guess what Creator/RobReiner's next film was?
* MemeticMutation: "When ______Met ______" . 20-something years later and people will recognize this as a riff on the movie's title.
** "[[DeadpanSnarker I'll have what she's having.]]"