* BigLippedAlligatorMoment: The introduction of Keroyon, where the rest of the group screams at his appearance, followed by a full-page spread of a man with a frog's head. Then he turns out to just be an ugly guy.
* CrazyAwesome: [[spoiler: Kenji]], after the second time skip.
* CompleteMonster: Both Friends were absolute monsters of a different variety
** The First Friend was responsible for 150,000 deaths by creating a plague and spreading it around the world, also causing widespread death and destruction in order to seize control of the planet and run it with [[DystopiaJustifiesTheMeans an iron fist]] where people are sent to nightmarish 'reeducation facilities' or high security prisons just for drawing manga. Friend successfully [[VillainWithGoodPublicity demonized the heroes and made himself a savior of the world]]. His whole motivation? Being a massive AttentionWhore and egocentric tyrant who wanted to be worshiped by everyone while satisfying a petty grudge against TheHero Kenji
** The Second Friend is an OmnicidalManiac StrawNihilist who, upon taking over from the first, proceeds to run the world even further into the ground. While the first Friend was a tyrant, the second simply wants to see everything burn. His actions are far more depraved and more and more people are killed under his reign. Even worse, he manufactures a new plague that he sends out with a twist: there is no antidote, only placebos. He simply wants everyone on the planet to die to satisfy his own cruelty.
* CrowningMusicOfAwesome: Kenji's song, Bob Lennon. It's a rare in and out of universe example, as a recorded version was released with the volume it was introduced in. Urasawa Naoki can sing, apparently.
** [[http://www.youtube.com/watch?v=-xdY10RhB0s#t=4m19s GUUUUTALAAAALA SUUUUUDALALAAAAAA!]]
* EarWorm: Kenji's song, Bob Lennon. As mentioned above, it's a rare in and out of universe example, as it plays a very important role in the plot as the story goes on, [[spoiler: especially the 'Gutalala Sudalala' version, which even the characters comment on as being an ear worm]] and since it was released in real life it can end up being stuck in your head very quickly.
* ItWasHisSled [[spoiler:There are two Friends, and the story goes ''way'' past the twentieth century.]] Surprisingly, Friend's identity is a well kept secret.
* MagnificentBastard: Friend
* NightmareRetardant: A mob of insane cultists swarming Kenji's shop to kidnap Kanna: Terrifying. A mob of insane cultists swarming Kenji's shop to kidnap Kanna while chanting "[[Music/DestinysChild DESTINY'S CHILD]]": a little goofier for western audiences.
* ParanoiaFuel: This series is the ''United Arab Emirates'' of Paranoia Fuel.