* DeaderThanDisco: Qualifies as this for great justice. Despite its then-revolutionary safe sex episode, having a character killed off due to AIDS, and boasting a respectable cast, it's better remembered nowadays 1) for the whole Valerie Harper debacle with Miller/Boyett and the way it was handled on the show, 2) as Creator/JasonBateman's StarMakingRole, 3) as an especially {{egregious}} case of KeepCirculatingTheTapes, and 4) for its theme song, especially to DeathMetal fans - Music/CannibalCorpse, of all people, has done the song live.
* EarWorm: The theme song "Together Through the Years".
* SugarWiki/FunnyMoments: The episode where David is a [[ItMakesSenseInContext "headless clown"]].
** Mark's nightmare in "Nightmare on Oak Street" where he suddenly forgets everything (i.e. he starts to eat cereal with a fork) and his parents find out why - he left his window open and his brain got eaten by zombies. The dream ends with them posting endless sticky notes on him.
** One episode has David making the twins believe he shaved his head. His hilarious expression of diabolical glee as he slowly pulls off the bald cap is one which must be seen to fully appreciate.
* HarsherInHindsight: In TheNewTens, Valerie Harper announced that she was diagnosed with brain cancer, thus rendering the entire death subplot as this.
* SugarWiki/HeartwarmingMoments: The family sticking together when their house catches fire. After David's speech about how he prayed that everyone else was OK when he got home and saw the house was on fire, they all sit down to dinner, and this happens:
-->'''Michael''': Would anybody like to say grace?\\
'''Sandy''': I think David just did.
* HeReallyCanAct: Creator/JasonBateman at times.
* {{Moe}}: Mrs. Poole. Sandy also has her moments.
* RetroactiveRecognition: Jodie Sweetin, known to the rest of the world as [[Series/FullHouse Stephanie Tanner]], played Mrs. Poole's niece in the season 2 episode "Boston Tea Party", which aired several months before ''Full House'' debuted.
* SeasonalRot: A lot of people think this of the show when Valerie Harper left.
* SeinfeldIsUnfunny: The condom episode became this over time when teen sex began to be discussed more openly on TV shows, such as the ones seen on Creator/ABCFamily.
* SpecialEffectFailure: The baseball thrown by Willie during the later seasons' opening credits is pretty obviously superimposed over the scene.
* WTHCastingAgency: [[Series/{{Today}} Willard Scott]] is a decent actor ([[{{Adorkable}} and he's pretty damn lovable]]), but ''how'' exactly did he get a role on this show? Granted, it was on an infrequent basis for about two seasons, but it's still pretty weird. Of course, he ''did'' have connections with NBC, being a popular weatherman there.