* SugarWiki/AwesomeMusic: [[http://www.youtube.com/watch?v=Q0c4NppdHeU The season 2 promo rap.]]
* BaseBreakingCharacter: Evan. Some fans find him completely annoying, others think that he's the best part of the show.
** Though as of late, he's become a much better character since he started dating Paige, to the point where when Hank was a jerk to him, Evan gave him a speech that was pretty close to a TheReasonYouSuckSpeech. Those who couldn't stand Evan before probably like him now. RescuedFromTheScrappyHeap indeed.
* DieForOurShip: The Foe Yay between Hank and Dr. Peck has ignited this.
* EnsembleDarkhorse: Paige went from hiring Evan to be her fake boyfriend mid-second season to being his real wife, part of the team, and PromotedToOpeningTitles.
* FoeYay: Hank and Emily. It gets more interesting when [[spoiler:they act on their attraction... in the ''second'' episode after her appearance. It doesn't look like they'll end the enemy stage just yet, either]].
* HoYay: Boris and Hank (Could be FoeYay depending on how the [[WMG/RoyalPains story]] is going), Evan and Boris (though more on Evan's part), Divya and Jill, [[IncestSubtext Hank and Evan]]
** [[SiblingTeam They're brothers; brothers do stuff like that.]]
** In 1x07, "Crazy Love", [[spoiler:the patient of the week gets put in an MRI. Something tries to get out of her ''chest''. Turns out to be an RFID chip, which is ''even more creepy''.]]
** In the season one finale, Evan finds mold in an attic. Moving, black mold. It is made marginally less creepy when it turns out to be bats.
** That one time where Hank drilled a hole in an old guy's head.
** "You Give Love a Bad Name" begins with [[spoiler: Hank opening the chest of a guy who has just been shot and instructing someone else to hold the ribs apart]].
** It didn't take long for Dr. Peck to be hated by the fandom. [[http://forums.usanetwork.com/index.php?showtopic=446778&st=0 Just check this out for an idea of how fans think of her.]]
** Molly, the bratty teenage daughter of Hank's new favored patient in season five, was also pretty unpopular with fans. It didn't help that she seemingly dedicated her life to making Hank's job harder.
** Evan watching helplessly as Hank tries to revive their father during his heart attack. Capped off when they finally get him to the emergency room and the surgeon - after asking what happened and if Hank is the primary physician to which Hank responds he's the son - can only reply with a shocked and sympathetic: "Jesus..."
** The revelation that Milos, Boris' seemingly diabolical cousin is in fact [[spoiler:severely mentally ill, to the point where he believes that Boris is hoarding a cure for his illness. It's especially sad watching Boris try to reason with him]].
* ValuesDissonance: Divya has to hide her work from her parents. She creates an elaborate cover story and enlists Evan to support it. The American viewer is probably thinking "You ''are'' over 21, right?"
* WTHCostumingDepartment: Season 7 opens with Paige and Evan having a bit of a PregnancyScare, as while they're married they're hardly ready to be parents. Towards the end of the episode, she shows up to tell him she's not pregnant after all; she got her period and was just late (even though she claims she's never late). The thing is, she's wearing '''white pants'''. Absolutely ''no'' woman on the first day of her period would be wearing white pants: if she was wearing them before she suddenly started, she'd change because they're now bloody; if she wasn't, there's no way she'd look in her closet for a new pair and go, "Hmm, I think I'll choose the one article of clothing most likely to advertise if my sanitary napkin springs a leak!"