* AlternativeCharacterInterpretation: There is certainly... something about the zombie that had been tested on in Umbrella's bunker. Given that he was becoming more aggravated when the researchers complimented him on the thinking abilities, as well as trolling them at one point with the camera, it could be that the test subject regained more humanity than it seemed to be and finally snapped when he was forced to play with children's toy and considered this too much of humiliation. As such, his breakdown and subsequent murder of two scientists can be seen as a display of not undead thirst for hunger, but rather very natural human anger at being treated like a mere guinea pig.
* AngstWhatAngst: That Angela "Angie" Ashford is nowhere to be seen and nobody ever mentions her is weird, but if we assume the novelization's stance that she died between the events of this and the previous film, then it is jarring that neither Alice nor Carlos seem distraught about it.
* AssPull: See the [[AssPull/ResidentEvilFilmSeries series' page]].
* SugarWiki/AwesomeMusic: For the first trailer, The Crystal Method's "I Know It's You", which included vocals by Creator/MillaJovovich herself.
* CommonKnowledge: Isaacs' first name is mistakenly believed to be Samuel by many, even though he was referred as such only in [=DeCandido's=] novelizations, which were rendered non-canon later on.
* CompleteMonster: The [[ActuallyADoombot first clone]] of [[MadScientist Dr. Alexander Isaacs]], while created to serve Umbrella, was too vile and egotistical to control. Isaacs experimented on clones of Alice, putting them through [[PlayingWithSyringes sadistic tests]] that resulted in 87 of them dying. He injects zombies with the blood of the Alice clones, resulting in them becoming stronger and attacking him and his fellow scientists, who Isaacs [[BadBoss leaves to die]]. Hoping that the real Alice's blood will domesticate the zombies, Isaacs attacks Claire Redfield's convoy with enhanced zombies in order to kill Alice, killing many people including Carlos Olivera. After being bitten by an enhanced zombie, Isaacs mutated into a monster and slaughtered everyone in his facility, betraying Umbrella for [[ItsAllAboutMe his own dark ambitions]].
* HilariousInHindsight: In [=DeCandido's=] novelization, Dr. Samuel Isaacs tries to prevent T-Virus from devastating the world, only resorting to ensure the corporation's own survival once the situation becomes hopeless, and afterwards blames Timothy Cain for unwittingly kickstarting the whole pandemic. Come ''Film/ResidentEvilTheFinalChapter'', and then we learn that [[spoiler:the outbreak in question was planned from the start by the ''real'' Dr. Isaacs]].
* {{Narm}}: The girl calling herself K-Mart because they encountered her in a K-Mart and she felt like changing her name. While this might have been intended to be taken as some kind of coping mechanism for a probable trauma (which is outright confirmed in the [=DeCandido's=] novelization), it doesn't stop it from being rather silly. It's even worse in the Spanish dub, where she is called ''Burger'' instead.
* QuestionableCasting: Creator/JasonOMara was disliked in his short role as Wesker, making fans somewhat relieved when he was be recast in the next installment.
* RescuedFromTheScrappyHeap: L.J. drops his ModernMinstrelsy shtick from the last movie and becomes an actual character rather than a "street flava" joke-dispensing device. [[spoiler:Unfortunately, it's only then that he gets killed off.]]
* SerialNumbersFiledOff: As mentioned in ''Film/ResidentEvilApocalypse'', the similarities between Alice's arc and the 1991 ''Literature/DarkWarrior'' OVA doesn't end in the previous film. In the sequel to the OVA, the evil corporation the protagonist fights again is led by a scientist in charge of a cloning project who receives orders from a holographic board of executives, not to count the corporation's head, a sinister, inexpressive blond-haired man who is even more superhuman than the main character. At some point, the scientist breaks away from the corporation and he and his bioweapons have to be put down by the protagonist, who then follows his path of revenge against the corporation. The scientist even looks a lot like Ian Glenn, and the board scene is so similar to the one from this film that it would be shocking that they are not an intentional ShoutOut.
* SpecialEffectsFailure: The scene of the mutated Isaacs killing Slater through his eyes and mouth has some seriously bad CGI on it, in contrast with most of the rest of the film.
* TheyWastedAPerfectlyGoodCharacter: Given that there is a teenage girl in the convoy who gets a lot of screentime, the viewer could be forgiven for guessing she's Angie after the TimeSkip instead of a new character named K-Mart. Had she really been written as Angie (either with the original actress or a recast, which would have been easy due to the mentioned time skip), many interesting storylines would have been possible thanks to her lingering T-Virus mutation and implied psychic bond with Alice. Instead, Angie is literally forgotten, and unlike Jill she never seen nor mentioned again in the franchise.
* TheyWastedAPerfectlyGoodPlot:
** Unlike film continuity, the novelization explains Angie's absence from the film as having been murdered by Alice under Umbrella's cybernetic mind control. Despite being a plot point that would have produced a great lot of drama and could have been used to give Alice more depth, nothing of this is used in the film proper, as Alice and Carlos are positively cheerful in their reunion and never dedicate a word to their vanished friend.
** Also unlike film continuity, the novelization also describes the main cast's adventures after ''Apocalypse'', the T-Virus outbreak as whole and Jill's story in the final chapters. And, just like above example, none of this is mentioned or ever referenced in the film, all we get is a small exchange between Carlos and Alice about what happened in Detroit, but what ''exactly'' happened is glossed over entirely and the film opens right ''after'' the T-Virus has ripped through the planet.
** The goal of Isaacs's simulations with the Alice clones is oddly never explained: he just says he is using their blood to try to make docile zombies, but that doesn't explain why he needs the clones to overcome the original Hive's obstacles, aside from the novelization mentioning he needs a personal army to take over what's left of the world. It's inevitable to think that, if the producers were going to include cloning and callbacks to the previous installments, they could have created many possible interesting plots instead of just because. This is admittedly exploited in ''Film/ResidentEvilRetribution'', but still very superficially.
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