* AuthorsSavingThrow: The developers explained that the reason why Crimson Heads were not included in ''[[VideoGame/ResidentEvil0 Zero]]'' (after being retroactively introduced in the ''[[VideoGame/ResidentEvil REmake]]'') is because Rebecca Chambers and Billy Coen don't spent much around the same place as Alpha Team in ''[=REmake=]''.
* DemonicSpiders:
** The leech zombies, without a shadow of a doubt. Tough as nails with an insanely long reach, they cause considerable damage when they hit and when they die they ''explode'' for even more damage. Luckily, [[KillItWithFire fire kills them]] fairly quickly, mitigating the annoyance a bit.
** Eliminators are small, soak up more damage than they have a right to, attack in packs, and like dodging bullets.
* EnsembleDarkhorse: Billy Coen, so much to the point fans desperately want Capcom [[spoiler: to reveal his fate.]]
** Despite the fact she's the focal character of the game, Rebecca Chambers is herself one as far as the series itself is concerned. Fans of her were more than pleased to see her get her own game and hope for more in the future.
* EvilIsSexy: The young James Marcus seems to have been invented for the sole purpose of adding more bishonen to the series.
* FanonDiscontinuity: Fans who don't like ''[[VideoGame/ResidentEvilGunSurvivor Resident Evil: Survivor]]'' have been known to use the aforementioned ContinuityNod to declare ''Resident Evil 0'' non-canon.
* GoddamnedBats: Actual bats, too!
* {{Narm}}: It's ''Resident Evil''. [[Narm/ResidentEvil What did you expect?]]
* NintendoHard: On the Hard difficulty, this is one of the stingiest in the series in terms of ammo and healing items. You'd better make every shot count, avoid enemies when possible and heal only when you are gravely injured... or else you ''will'' find yourself [[UnwinnableByDesign screwed over sooner or later]].
* ScrappyMechanic: The inventory system often means having to ferry stuff you need from one area to the other.
----