* CrowningMomentOfAwesome: Sheldon turning down Amy's advances, and telling her to try again once she grows the hell up.
* CrowningMomentOfFunny: Sheldon and Cooper decided to switch seats while waiting for [[spoiler:the results of Pete's surgery]] based entirely off events that happened [[OneOfOurOwn beforehand]].
* CrowningMomentOfHeartwarming: When Cooper [[spoiler: finds out that Charlotte was raped, he sits down with her, tells her he loves her (no matter what), vows to protect her, and ultimately helps her find the strength to identify her rapist]]. May also be a TearJerker for some. It was just that good.
* EnsembleDarkhorse: Charlotte, for many fans, once she was defrosted. Probably helps that [=KaDee=] Strickland pulls off the whole Southern-Belle Texas-accented charm with perfect ease.
* FanPreferredCouple: Pete and Violet as of now, Cooper and Violet in season 1, later Cooper and Charlotte until recently (see {{Jerkass}} example below).
** Addison and Sam. ADDISON AND SAM, until recently when he started getting indecisive.
** Also, Naomi and Gabriel.
** Addison and Jake, on the grounds he actually likes kids and her.
** Sheldon and Amelia have a pretty passionate fan base, although Ryan and James don't often get the DieForOurShip treatment ([[spoiler: although that may be because Ryan did]]).
* FunnyAneurysmMoment: Early in Season 3, in order to get some perspective on one of her patients, Violet poses Cooper a hypothetical: [[spoiler: Charlotte is raped, falls pregnant by the rapist, and decides to keep it. Cooper responds with "Don't hypothetically rape my girlfriend!". A year later, Charlotte being raped is no longer a hypothetical.]]
* GrowingTheBeard: Every fan will have a different answer to "When did the show completely step out of the shadow of ''Grey's Anatomy'' and become its own entity?", but they can all agree that "Did You Hear What Happened to Charlotte King?" is a contender.
* HarsherInHindsight:
** In an early episode that dealt with STD's, Maya reassures her mother that she's still a virgin. A couple years later [[spoiler: she gets pregnant.]]
** Sheldon turning down Amelia's advances to him becomes this when [[spoiler:her drug addiction resurfaces and]] he develops a massive concern for her. He even lampshades it as a regret.
* HilariousInHindsight: Sam in episode 2 of the first season, upon seeing Charlotte, declares her not a member of the Practice... a season or two later...
* JerkassWoobie: Charlotte, as of [[spoiler: the episode in which she was brutally raped and beaten]].
** Lately, more Jerkass than [[TheWoobie Woobie]]. Looks like she's back to her old horrible self.
* TheScrappy: [[RuleOfCautiousEditingJudgement Let's just say that some characters were worthy of that sinister title in some seasons]], prior to CharacterDevelopment. Initially Violet was one, but slowly pulled herself out of this category. Then Sam became one because of his treatment of Addison in late seasons.
* ShipSinking: Cooper and Violet after he got together with Charlotte and lost his feelings for Violet.
** Addison and Pete at the end of Season 3, when they respectively choose Sam and Violet.
** Sheldon and Amelia, after she straight-up tells him she'll never love him back during her intervention.
* TheWoobie: They take turns. Actually, there isn't a single character who didn't end up as the woobie at one point or another in the show.
* {{Wangst}}: Holy shit, where to even start? Let's just say these people make [[Series/{{Supernatural}} The Winchesters]] look like a perfectly happy, well-adjusted, picket-fence-rockin' family.