* ArcFatigue: The comic had good pacing at the start of the series, but past the "Rescue Blossom" arc, things came to an rather annoying crawl, with the hiatuses not helping matters. For clarity, the comic's main plot started in 2004 and shaped up to be a standard heroes vs villains type of thing. At the time of this writing (2023), that conflict ''still'' hasn't really come to fruition nor what the villains are really planning.
* EnsembleDarkhorse: Bell. The amount of fanart she gets is staggering.
* EpilepticTrees: Bell. Is she a clone? A real Powerpuff Dr. X created? Someone who just has similar powers? Bleed originally [[http://bleedman.deviantart.com/#/d34saim envisioned her as a android]], so that's also a possibility.
* HilariousInHindsight:
** Bleedman draws the Powerpuff Girls grown up and with more realistic, anime style bodies. Then, a year later, ''Anime/PowerpuffGirlsZ'' was announced.
** Also with the Rowdyruff Boys, whose new appearance in the comic predated their return in the TV show.
** And then came ''VideoGame/FusionFall'', which seems to rip off Bleedman's style wholesale.
** Jack's presence also predates [[SamuraiJack/TropesSeason5 Season 5's]] premise of still being in the future without having aged a bit.
* HypeBacklash: Back in the day, the comic generated a lot of hype, but nowadays, there are a lot of factors that can cause this and HypeAversion.
%%* JerkassWoobie: Bell and Mandark.
%%* LesYay: Bubbles' girl-crush [[https://www.snafu-comics.com/powerpuffgirls/jenny-is-now-friends-with-bubbles on]] [[https://www.snafu-comics.com/powerpuffgirls/food-for-thought XJ-9]].
* {{Moe}}: Bell. Drawn in a style much more reminiscent of the original Powerpuff Girls than the girls themselves and refers to [[WesternAnimation/InvaderZim GIR]] as "GIRLY".
* RescuedFromTheScrappyHeap: For 2018's April Fools Day joke, [[WesternAnimation/ThePowerpuffGirls2016 Bliss]] was put into the comic as the school's guidance counselor. Despite the negative reputation of the reboot, fan reaction to this was mostly positive, her design especially being praised. Some even hope she'll make other appearances outside the joke comic.
%%* ViewerGenderConfusion: The Rowdyruffs.
* ShipToShipCombat: While there are fans of Dexter and Blossom's relationship, there's a vocal portion of the PPGD fandom that prefers to ship Blossom with her Rowdyruff counterpart, Brick. The writer reinforcing that Dexter and Blossom were and always will be set as the OfficialCouple of the series didn't help quell the discourse either.