* {{Defictionalization}}: Since the film's release, A marijuana strain named Pineapple Express was bred from crossing Trainwreck and Hawaiian
* HilariousInHindsight:
** Creator/AmberHeard being shocked that someone would call her a lesbian. It was probably more an ActorAllusion because even though she wasn't out, the cast (including writer Creator/SethRogen) likely knew.
** Angie's MayDecemberRomance with Dale is pretty funny considering that Amber Heard was once married to the much, ''much'' older Creator/JohnnyDepp.
** ''"If marijuana is not legal within the next five years, I have no faith left in humanity--period!"'' Sure enough, Washington and Colorado became the first US states to legalize recreational marijuana use in 2012, just four years after the film came out which also makes this HeartwarmingInHindsight.
* HoYay: "I'm gonna save you, man!"
* OneSceneWonder. Creator/BillHader plays a US Army soldier given marijuana to see [[IntoxicationEnsues how it effects him]]. HilarityEnsues.
* RetroactiveRecognition: Creator/KenJeong has a small role in the film as a MookLieutenant who leads the attack on Ted's farm compound. He gets to say a few lines and plant the bomb that kills Ted.
* {{Squick}}: Dale trying to put part of his ear back on after getting a piece of it shot off by a gun.
* ThisIsYourPremiseOnDrugs: ''Film/HotFuzz'' or ''Film/DieHard'' on weed.
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