* CompleteMonster: [[DragonInChief Number 9]] is a psychotic, sentient Golem designed by Neo Ark to keep AMNC subjects under control. [[WasOnceAMan Originally a human]] who personally requested to become a Golem, he paid the scientists to retain his human intelligence and memories after the transformation. Becoming a "Hunter" for Neo Ark, he leads an attack at the Arkopolis Tower that kills many people, sending in AMNC mimics to kill the SWAT team. He later attacks [[PlayerCharacter Aya Brea]]'s partner, Rupert Broderick, in a church, escaping when Aya sees him. Attacking Aya on top of the tower, he sets off a series of explosions that destroy the tower and the people inside. Ordered to use [[EldritchAbomination the Pupa]]'s powers to unleash a virus that would cause every human on earth to turn into [=AMNCs=], he sends Agent Kyle Madigan to lure Aya to the underground Neo Ark labs, where she frees the young Eve. Afterwards, he kidnaps Eve, [[WouldHurtAChild threatening to kill her]] if Aya tries to stop him. Planning to use Eve's powers to awaken the Pupa from its cocoon and make it stronger, he orders Kyle to kill Aya.
* ContestedSequel: Being a ''massive'' departure from the original in almost every way means that quite a lot of people really hate this game.
* DemonicSpiders: The Golems due to their speed, hard hitting attacks, and high HP. Some of them can even cause Poison or Paralysis on you to boot and in certain areas, you fight more than one Golem at once. Nightmare Mode makes ''every'' encounter demonic spiders due to Aya's massively decreased HP and defense.
* FakeDifficulty: Square tried to make ''II'' more like the ''Franchise/ResidentEvil'' games, but with [[CameraScrew worse camera angles]] and an absolute lack of a quick, 180-degree turn. Many cheap shots and deaths will ensue. The original game generally favored more isometric viewpoints that, what a surprise, showed most of a room without any awkward and abrupt angle transitions.
* FollowTheLeader: After doing its own thing in the first ''VideoGame/ParasiteEve'' game, Squaresoft decided to ape ''Franchise/ResidentEvil'' for this one, resulting in Aya investigating a seemingly abandoned area where an outbreak of man made monsters is occurring, eventually leading her to a secret underground base run by a powerful group with a lot of money and NoOSHACompliance. Also, SolveTheSoupCans puzzles and tank controls.
* FridgeBrilliance: If you examine Bowman's bed several times, Aya will note that there are clumps of hair on the pillow and foul-smelling stains on the sheets. Hair loss and altered body odor are both common side effects of chemotherapy, which goes a long way towards explaining why Bowman was eager to volunteer for the experiment.
* GameBreaker: Naturally, several of the weapons you get as rewards for NewGamePlus qualify.
** The Javelin underbarrel attachment [[note]]You can actually get this one in your first playthrough, but very late in the game.[[/note]] for the M4 assault rifle is a weapons-grade laser. It has good damage output, has a damage type that enemies have no resistance for, and holds an impressive 60 charges. And like all equipment running on batteries, you can charge it up for free at points where you can buy items.
** The Hypervelocity gun shares all of the above advantages with the Javelin in a standalone weapon, along with being even more damaging and holding a whopping 100 charges.
** The Gunblade is a shotgun with a huge blade attached to it. Shotguns already tend to be useful in the game, with the biggest downsides for ones you can get early being low ammo capacity and low rate of fire due to them being pump-action. The Gunblade avoids both, and striking enemies with the blade itself, while slow, has a decent range, high damage and also deals a damage type no enemy is resistant to. Finally, you can time firing the shotgun at the same moment the blade connects, which causes ''enormous'' damage in a single strike!
* GeniusBonus: If you actually know what "Neoteny" means, a bit more of what the cult is trying to do makes sense. Well, as much sense as the intentions of a cult usually make. Neoteny is a term referring to an "adult" lifeform, showing traits from a younger form (the classic example being the axolotl; a species of salamander which retains the fins and gills which most other species of salamander lose after growing out of their larval stage). So basically, the cult is trying to "revert" humanity into more primitive forms in order to "reboot" humanities evolutionary process (somewhat ironic, given some researchers argue that a lot of the traits that set humans apart from other primates are neotenous).
* {{Narm}}: A lot of the [=ANMCs=] have really goofy looking faces for such hideous monsters, possibly because they look somewhat human from the transformation.
** The fat ANMC[=s=] and the aquatic ones make a silly "Ohh" noise when they are attacked or attack, respectively.
** Many people also seem to agree that the horse-like sound the creature the young woman at the Akropolis café transforms into effectively ruins the scariness of the scene.
* NarmCharm: No. 9 has several lines which sound bizarrely out of place, but that ends up making him a more memorable and entertaining villain, as well as gives him a feel of mental instability.
* ParanoiaFuel: The Stalkers are chameleon-like monsters with an InvisibilityCloak. Unlike other monsters in the game, they can't be seen if they are in a room. You will only know if they are there if you suddenly enter the battle screen to a very loud, unnatural screeching noise.
** Knight and Bishop Golems are even worse. You don't detect them until they attack you, and they always land the first hit.
** In-universe, the Stranger AMNC's can shift from their monstrous forms to a human form, which not only catches Aya completely by surprise, but caught an unwary S.W.A.T team with their pants down, leading to their demise. Sadly, in-game this ability is rather under-utilized.
* TheyChangedItNowItSucks: In the eyes of many fans, Squaresoft tried to make it like ''Franchise/ResidentEvil'' a little too much, ditching too many of the RPG elements to make a game that was a derivative clone of Capcom's survival horror flagship.
* {{Tearjerker}}: If you take too long in the fight against the Burner boss, [[spoiler: Mr. Douglas' dog Flint dies]]. [[YouBastard It was your fault, because you took too long killing that thing.]]
* UncannyValley: Most of the [=ANMCs=] in the game are animals with vaguely human-like characteristics. 'Strangers' are Ostrich/Dinosaur-like things that can mimic corpses and 'Chasers' are basically camels with horrifying, polygonal human faces. Their subspecies 'Mad Chasers' fall on their backs and ''start laughing'' when Aya attacks them.
* VisualEffectsOfAwesome: The sheer amount of attention to detail found throughout each level design of the game is stunning, and just like the previous game, the beautiful graphics still hold up today.