* AlternativeCharacterInterpretation: Jimmy himself even questions if Oryx as UnreliableNarrator is an issue. Was she both girls or did she make that up?
** On Crake's side there's how much of a chess master was he? Certain parts seem to imply he's been playing everyone, but some of these parts aren't ever confirmed outright.
* {{Anvilicious}}: Playing God is not a good idea.
** Technology will kill us all! [[MediaScaremongering Time to panic!]]!
* HilariousInHindsight: As of 2013 there is now lab-grown meat from stem cells.
* NightmareFuel: all of it. seriously.
* SciFiGhetto: Margaret Atwood once insisted that this isn't science fiction, it's speculative fiction.
* {{Squick}}: Some parts fall very much into this.
** Oryx's backstory, in which she was a child SexSlave. This is not simply stated to the reader, either; instead, it takes up the better part of a chapter.
** The effects of the [=BlyssPlus=] experiments, although some may fall into CrossesTheLineTwice territory.
* TooBleakStoppedCaring: Even before the actual apocalypse, the future presented is ''so goddamn bleak'' that it can be hard to get through the whole book.
* WhatDoYouMeanItsNotSymbolic: Lots.
* WordOfGod: Atwood says that Crake AKA Glenn is heavily based on Canadian pianist Glenn Gould and has Asperger's Syndrome.
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