* HarsherInHindsight: The premise of a globally distributed drug turning out to be deadly hasn't aged well since the UsefulNotes/COVID19Pandemic, specifically the paranoia around whether the developed vaccines were safe due to being made relatively quickly.
* InferredHolocaust: No outcome of this game is actually positive. Even the GoldenEnding leaves John and his daughter in a completely dead world, doomed to eventually die of starvation.
* ScrappyMechanic: The author wasn't kidding when he said he wouldn't put a replay feature in... (There is a workaround for this, though, just like in ''VideoGame/OneShot''.)
* EnjoyTheStorySkipTheGame: The gameplay is very simplistic to focus on the deeply tragic and emotional story.
* TooBleakStoppedCaring: Just about everyone is going to die, just about every ending is a {{Downer|Ending}}.
----