* HarsherInHindsight: A few of the cats that Jackson has saved can become even more tragic thanks to certain events learned later on after the episode aired. For example, Lux the "911 cat" with a condition that can cause him random pain at times becomes more tragic when it was revealed that the initial foster family also had to re-home Lux, as his condition worsened beyond their ability to handle, to the point that it seems the original family may have been ''under-reporting'' the intensity of the incidents with Lux. Thankfully, a new foster family and new meds seem to be having better luck.
** One of Jackson's favorite kittens from the kitten rescue transport, Mojito, was the subject of a later episode as she was driving her new family more than a little nuts with her aggression. Thankfully most of her aggression was misdirected play energy, and the children of the family ''did'' love her very much so there was little chance of rehoming even with the problems.
* {{Squick}}:
** Whenever an owner has an inadequate litterbox, Jackson takes out a blacklight and usually reveals urine stains everywhere ''except'' the litterbox.
** Or if the litterbox itself is fine, but the owner has been negligent in cleaning it out.
** Also, how does Jackson sometimes inspect the litterbox? By ''running his hand through the litter.'' True, it's to gain information, and he acknowledges that it's gross, but still.
** Bandit & Gypsy Rose had started a "pee war" which escalated to the point where the owners had to cover the entire house with plastic. [[spoiler:It turned out that they weren't fighting with each other, but with stray cats that were coming in through open windows.]]
* TearJerker:
** Occasionally, Jackson meets an owner who had recently lost a pet and finds it hard to move on. Often, when this happens, they memorialize the old pet as a way of symbolically letting go. One of these episodes even had an "In memory" card for one of Jackson's own pets at the end.
** For cat lovers, it can be a TearJerker to watch some of the owners insist that their cats have good sides and just need help, especially if other people in their lives are insisting on measures like euthanasia. One of the most touching of these moments was with Einstein. One of his owners was a young boy who broke down on camera while saying how much he loved the cat.
** One Season 5 episode ended with [[spoiler: the owners surrendering their cat to a foster home]] because of his Feline Hyperesthesia Syndrome. While the cat turned out happy and the owners did too, it was heartbreaking to watch.
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