* HilariousInHindsight: The comic was created well before ''[[VideoGame/MetroidPrime Metroid Prime 3: Corruption]]'' was originally announced which eventually used some of the elements found in the comic. {{Lampshaded}} by [[WordOfGod Reynard]] in [[http://bobandgeorge.com/comics/metroid/411/1 a filler]].
--> '''Reynard''': "I just want to know if someone at Retro reads the comic. Maybe I'm psychic."
** [[http://bobandgeorge.com/comics/metroid/138/1 Samus playing]] ''VideoGame/{{Tetris}}'' before her appearance in ''Tetris DS'' was announced.
* MemeticMutation: The filler strips introduced the Internet at large to the eccentric reimagining of ''VideoGame/MegamanBattleNetwork'' villain Flashman.exe: [[FanNickname Shoulderman]].