* AlternativeCharacterInterpretation: During the scene where [[spoiler: Yuki reveals to the audience that Garai raped him in dialogue, it's unclear if he's so deranged that he genuinely doesn't understand how someone could be offended by it, or if he's deliberately doing it to drive the nail in further.]]
* CultClassic: It’s not the most famous manga Creator/OsamuTezuka has ever made, but it’s received plentiful acclaim for its nail-biting plot, ValuesResonance, [[DarkerAndEdgier mature tone]] and being rumored to have been the influence of Manga/{{Monster}}.
* CrossesTheLineTwice: Michio's complete and utter disgusting behavior becomes this at a certain point. What else can you call injecting a woman you're currently having sex with a neurotoxin that both kills her and causes her to orgasm, then pretending to kidnap her and imitating her ForTheEvulz?
%%* HoYay: Michio and Garai.
* JerkassWoobie:
** Father Garai is a devoted priest and the long-suffering boyfriend of Michio Yuki. Garai initially refuses to turn in Michio to the authorities, believing it to breach his authority as a man of god, and assists Michio in committing many of his crimes, along with [[spoiler:raping Michio when he was young, which, along with the MW bioweapon, exacerbated Michio's transformation into TheSociopath.]] Despite this, Garai clearly regrets going along with Michio's schemes, eventually resolving to stop him, and is put through continuance abuse, ending with him [[spoiler:[[HeroicSacrifice killing himself]] in order to save the world from MW.]]
** Michio drives the "Jerkass" part well past its breaking point, murdering children and raping random women for fun, and [[spoiler: attempting to annihilate the entire world for his own amusement]], but it becomes increasingly obvious that any legitimate chance at a normal, happy life he had has been completely annihilated by being horribly brain-damaged, he's slowly, painfully dying and he [[spoiler: witnesses the only person he remotely cares about die attempting to stop his plans to destroy the world]] in front of him.
* LoveToHate: Michio Yuki is a piece of murdering, raping scum, but damn if he isn't fun to watch.
* MindGameShip: Michio and Garai.
* {{Narm}}: Michio is supposed to be really evil, fair, but [[spoiler: stuffing a guy's mouth full of cigarettes until he falls off a cliff and raping your dog]] is so terrible it's almost LaughablyEvil.
* NarmCharm: That being said, Michio's psychotic crimes do demonstrate what how twisted and sadistic his sense of humor is.
* NightmareFuel:
** Michio. He extorted money from a man with intent to murder his kid, and then does it anyway and then admits it to Garai while pretending to [[JerkWithAHeartOfJerk feel guilt.]] And that's only the '''first chapter'''.
** The MW gas. It obliterates an entire village, and even a tiny portion of it turned NiceGuy Michio Yuki into a deranged monster.
* TearJerker:
** Michio is a complete and utter monster, but it's not his fault. He was a perfectly nice kid before he was exposed to MW, not to mention being [[spoiler: raped by Garai in the process,]] and he suffers constant physical pain because of it. While this fails to excuse one inch of his depravity, it might make you feel an ounce of pity for him.
** Garai's [[spoiler: HeroicSacrifice, especially since he did it mostly in vain and Michio, or at least his now-evil brother is still alive.]]
* TheyWastedAPerfectlyGoodCharacter: Anytime Sumiko seems to have any influence on the main plot, it is frustratingly subverted. Most prominent example is when she [[spoiler:told Michio's fiancé about their relationship, but the fiancé shrug her off and didn't even hesitate in marrying Michio]].
* TheyWastedAPerfectlyGoodPlot: Michio never do anything to interfering with Meguro's investigation into him after the first few chapters.
* TrappedByMountainLions: Sumiko's entire sub plot has absolutely no bearing on the main story beside providing some heterosexual sex scenes. Even when the one time where she is relevant to the plot, [[spoiler:informing Michio that Garai is willing to leave the priesthood to stop his plan]], the impact of the scene could have been greater if it comes from Garai himself.
* ValuesResonance: While Michio is a DepravedBisexual, the depictions of most of the other LGBT characters are rather positive.
* TheWoobie: Michio [[UsedToBeASweetKid as a child,]] and only as a child. He gets abducted while on a boat with his father, raped in a cave, and exposed to a dangerous chemical that turns him into the [[TheSociopath abomination]] he is now.
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