* NauseaFuel: This manga doesn't shy away from showing all the dark parts of medical profession.
** The fetus in the man's brain, the one which ends up sending Jin to the past. A full-blown FetusTerrible, bloodied and landing straight into WombHorror.
** The victims of cholera are shown both puking and suffering from severe diarrhea, and no VomitDiscretionShot for us, oh, no. ''Jin'' goes for close-ups!
** Jin's opponent's cholera choses to manifest itself as he stands up to confront him, ending with the man vomiting right into Jin's face.
** The description of syphillis' patients' problems - her bones are rotting, her muscles are rotting, her nose has ''already'' rot...
** When Jin opens a patient's skull, blood spurts out of it straight into the "camera".
* {{Squick}}:
** Open-brain surgery -- with carpenter tools. And a bursting cerebral edema. Also, it's hard to preserve much dignity when suffering from cholera and a cholera epidemic is no fun for anyone.
** There's also the geisha girls dying of syphillis and other venereal diseases. The withered, skeletal looks on their faces simultaneously bring out [[NightmareFuel Nightmare Fuel]] and [[TearJerker Tear Jerker]].
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