!!Comic:

* DarknessInducedAudienceApathy: A minor problem with the first six-issue arc of IZombie. Nothing is resolved, the BigBad is a 'good' guy, who can't be hurt, and the main star has no collection to things going on.

!!Series:

* MoralEventHorizon: After first being shown to apparently be willing to leave his old life of drug dealing, once he finds out he can turn ''others'' into zombies and uses this to make a brain-dealing business, Blaine establishes himself as a villain. But what crosses this is when its revealed that his source of brains for his operation is actually troubled teenagers who he kidnaps and kills, rather than his claim of grave digging.
* TheyChangedItNowItSucks: A peeve of some fans, save for the brains and zombie thing. The TV Series barely resembles the comics. They don't even use the name of the original character. With that being said it ''has'' gained acclaim from television critics.
* WhatAnIdiot: Despite knowing that she was a medical examiner for the Seattle PD, one of the suspects in "Brother, Can You Spare a Brain?" actually tried to rape Liv. Made even worse due to the fact that he knew her partner was right upstairs. As you can guess not only did he get his ass kicked by both of them he was arrested instantly. Of course, he seemed to think she ''wanted'' to have sex with him (thanks to the effect of the brain-of-the-week) and so he probably didn't think it was rape, which sadly crosses into TruthInTelevision.