* {{Anvilicious}}: Corporations = death of creative ideas. Even without Jhonen saying it, you can tell this is him burning any leftover anger at Nickelodeon.
* CrossesTheLineTwice: Well... Way More Than Twice: But what were you expecting?
-->'''Devi''': OH GOD! EDDIE? Talk, Eddie! Let me know you're not dead! C'mon Eddie! C'MON!!\\
'''Eddie''': Hmph...Gugh...\\
'''Devi''': Oh thank god! Come on! Keep talking Eddie!! Stay with me! STAY WITH ME!!\\
'''Eddie''': Can I touch your butt?
* GeniusBonus: Eric the Vampire's friend who dresses up as a mummy uses swarms of bees instead of smoke to make a dramatic entrance. This may seem like a typical example of Vasquez's trademark random jokes but honey was in fact often used to preserve bodies in Egyptian tombs.
* HarsherInHindsight: Vasquez uses this comic to tract about the pains of working in the corporate-driven animation industry, and how working independently was easier after the frustrations involved in show-running ''WesternAnimation/InvaderZim''. While he would continue working in the industry as described below, he ended up having an even worse experience involving Creator/{{Disney}} over a decade later. Not only was his and Jenny Goldberg's experience producing a pilot called ''Very Important House'' somewhat demoralizing, but they also [[ScrewedByTheLawyers lost the rights to it despite the company not green-lighting it]].[[note]]On Disney's part, this was probably to avoid an ''WesternAnimation/AdventureTime'' scenario, in which another company would pick it up and [[AndYouThoughtItWouldFail see success from it]], as they themselves may have only passed on it because of ''WesternAnimation/StarVsTheForcesOfEvil'' carrying a similar tone.[[/note]] Working on character designs for ''WesternAnimation/RandyCunninghamNinthGradeNinja'' at the same time as producing the pilot was meant to be a brief respite from the more frustrating parts of making it, while ''WesternAnimation/InvaderZimEnterTheFlorpus'' actually occurred in part because Vasquez felt so miserable after the experience with Disney that he wanted to do something that would really cheer him up.
* SugarWiki/HeartwarmingMoments: Devi and Tenna's friendship moment at the end. Given how much shit the latter's been putting up with since the former started having issues (Hell, in this comic alone), it's really amazing that Tenna's stuck by Devi like she has. Especially since the creator is Vasquez.
* HilariousInHindsight: Vasquez, despite having written a thinly-veiled metaphor for the pains of working in the corporate-driven animation industry and how much easier things were when he was working for himself, would end up going on to do more work in animation years after ''Invader Zim'' ended production, producing stuff for Creator/{{Disney}}, Creator/FrederatorStudios, and (once again) Creator/{{Nickelodeon}}. He would even begin to speak more fondly on his experience making ''Zim'', though he would regularly stress that he still greatly prefers the quicker turnaround involved with making comics compared to animation (hence why that was a movie [[WhatCouldHaveBeen instead of a television show or miniseries]]).
* JerkassWoobie: Yes, Devi is being [[MindRape mentally assaulted]] by a [[DoesThisRemindYouOfAnything parasite her murderer once-date accidentally gave her]]. Yes, she is under [[ExecutiveMeddling a lot]] of stress. Yes, she is often an utter bitch to her best friend, laughs with her at the idea of some random dude setting himself on fire, throws a little girl and stomps a cat to death, and [[ArsonMurderAndJaywalking spams F-bombs.]] Read the comic and there's more! [[ProtagonistCenteredMorality What.]] [[CrapsackWorld The.]] [[WhatTheHellHero Fuck.]]
* RealitySubtext: Devi, much like Vasquez [[WesternAnimation/InvaderZim was at the time]], transitions from creating art for herself to doing it for a corporation, and finds herself irritated at the constant demand for revisions that make no sense with her creative vision and are introduced entirely to appeal to certain demographics.
* SugarWiki/MomentOfAwesome: The fact that [[spoiler: ''Devi is able to stop Sickness from ruining her life and making her like Nny'' fits here]]. Especially considering [[spoiler: '''''the usual shtick in the worlds of [[SadistShow Jhonen Vasquez]]''''']].
* TearJerker: Finding out that not only did [[spoiler: Devi accidentally kill one of her classmates by blowing chalk in his face, causing him to have a fatal allergic reaction, that student would have been her only chance at a sound romantic relationship.]] Ouch.
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