* SugarWiki/AwesomeMusic: [[https://youtu.be/vdmBqZDzpM8 "Trepanation"]] by Millennium Parade, which was used for both the opening and closing credits of the live-action adaptation, is a rather avant-garde yet engaging art-pop number.
* CrossesTheLineTwice: Nakoshi [[spoiler:jacking off onto his resignation slip]].
* HoYay: Nakoshi and Itoh. [[spoiler: Except not really because Itoh is a trans woman.]]
* {{Narm}}: The final volume's climactic scene of Nakoshi [[spoiler:[[ScrewYourself shagging the daylights out of a female version of himself]]]] has as much potential to be horrifying or hilarious as dramatic.
* NauseaFuel
* NightmareFuel: Many of the homunculi shapes.
* {{Squick}}:
** Nakoshi eating his own semen, and Yukari drinking her blood.
** Later on, when Nakoshi [[spoiler:does his own trepanation, and ''sticks his finger in the newly formed hole'']], all in a public toilet!
* TheyChangedItNowItSucks: The live action version changes a number of things around after the second half of the program, including the source of Itoh's insecurities and more importantly Nakoshi's entire backstory [[spoiler:including his deteriorating mental health in the finale]]. Some fans were not pleased with the outcome.
* TearJerker: The epilogue.

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